27Dec

Agmatine Sulfate: Usage, Dosage and Benefits

Agmatine Sulfate is the supplemental form of Agmatine. Agmatine, on the other hand, is a very common chemical found in animals, plants, and bacteria. Even humans naturally produce this compound from an amino acid known as L-Arginine. The chemical acts as a neurotransmitter found in neurons. According to some scientists, the chemical affects various parts of the brain. It interacts with different receptors to produce different effects. It has been linked to a number of health benefits ranging from cognitive enhancing benefits to improved athletic performance, enhanced mood, and stress relief. However, the research backing these effects is very minimal.

Supplements like this one have not been approved by the Food and Drug Administration for any medical uses. They are also unregulated, which means you can easily buy them from online and other stores, but the quality of the compound may vary from one vendor to another.

Working Mechanism

Scientists have put across several possible working mechanisms of Agmatine. According to some data, the nootropic interacts with several enzymes that play a key role in the production and functioning of Nitric Oxide. Research suggests it inhibits two enzymes, iNOS, and nNOS. iNOS is involved in the production of Nitric Oxide to support the immune system. However, at high levels, it can trigger inflammation, which can lead to serious medical complications. It prevents this by inhibiting iNOS.

nNOS, on the other hand, supports the communication of neurons, but at high levels, it prevents the growth and repair of neurons, which can lead to neurodegenerative issues. This partly explains why supplements are said to be a possible solution for neurodegenerative disorders like dementia.

Finally, Agmatine increases eNOS enzymes, which facilitate the vasodilation of blood vessels. This increases the flow of blood, ensuring that cells and tissues are getting sufficient oxygen and nutrients. It also helps to lower blood pressure.

It is also known to affect other parts of the brain. For instance, some trials report that it blocks NMDA receptors to fight neuron damage and death caused by glutamate toxicity.

Agmatine also prevents the learning neurotransmitter acetylcholine from binding to nicotinic acetylcholine receptors. Agmatine binds to these receptors hence allowing your brain to make use of acetylcholine.

Animal studies also show it can increase beta-endorphins by activating imidazoline receptors. An increase in beta-endorphins improves one’s response to stress, fear, and pain.

These are just but a few of the suggested mechanisms of action of this chemical. It’s critical that you understand the chemical has only been tested in animals and cells. Therefore, its full effects on humans are still not 100% understood.

Uses and Benefits

According to the preliminary data we have at the moment, Agmatine Sulfate may be useful for the following conditions:

  • Mental Health

From animal studies, it was seen to improve subjects’ responses to stress, anxiety, and depression. These effects have not been studied in humans, so we don’t know whether the drug can produce similar results in adults with the same conditions.

It is said to be effective for these conditions by boosting adenylate cyclase levels in the prefrontal cortex of animals. Low levels of this enzyme have been linked to depression, so it helps prevent it by increasing the enzyme.

In addition to that, Agamatine increases NRF2 to protect the brain cells against cortisol.

  • Pain

Agmatine may decrease hypersensitivity to pain. In some animal studies, the chemical reduced neuropathic pain by blocking NMDA receptors and inhibiting the activation of nitric oxide synthase.

The effectiveness of the drug for pain management in humans remains unknown since the drug has not been subjected to any reliable clinical trials. Therefore, it’s best to consult a physician before using agmatine sulfate for this purpose.

  • Brain Health

It could be a potential treatment for the symptoms of Alzheimer’s disease, seizures, stroke, and nerve damage. It can also prevent these conditions.

Agmatine sulfate is believed to be effective for Alzheimer’s disease because it fights the buildup of plaque and neurofibrillary tangles by improving insulin signaling.

For seizures, agmatine sulfate was seen to be effective in mice where it blocked NMDA receptors, which have been linked to the condition.

It also improves nerve repair and growth by inhibiting nNOS.

None of these benefits have been confirmed in human trials, so consume this data with a grain of salt.

  • Muscle Growth

In one animal trial involving rats, Agmatine stimulates the secretion of Luteinizing Hormone, increasing the production of testosterone. Testosterone plays a vital role in the growth of lean muscle mass, fat loss, sex drive, and other body functions.

Agmatine also improved insulin sensitivity and glucose uptake in the muscles.

This explains why agmatine sulfate has been linked to improved athletic performance.

Other possible uses of agmatine sulfate include:

  • Treating inflammation
  • Easing alcohol and morphine withdrawal
  • Treating atherosclerotic lesions (hardening of arteries)
  • Weight management
  • Improving insulin sensitivity
  • Treating symptoms of herniated disc
  • Treating psychiatric conditions like Schizophrenia

Side Effects

Agmatine can produce side effects like:

  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach upset

It should not be used with alcohol as it increases the risk of getting ulcers. To avoid drug interactions, consult a licensed physician before taking agmatine sulfate if you are already using other medications.

Pregnant and breastfeeding women should avoid it.

Dosage

There are no official dosages. The appropriate dosage could vary depending on the condition you are treating, your age, and health status. For instance, to treat neuropathic pain, dosages between 1 and 2.5g per day were used in most studies.

Consult a licensed medical practitioner for a more appropriate dosage guideline. They will also help you identify other possible alternatives to agmatine sulfate.

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References

  1. https://www.ahajournals.org/doi/full/10.1161/circulationaha.105.602532
  2. https://pubmed.ncbi.nlm.nih.gov/12543244/
  3. https://www.nature.com/articles/s41598-019-49078-0
27Dec

The 3 Best Nootropics for Energy and Motivation

Nootropic supplements, sometimes referred to as brain-boosting supplements, were developed to enhance the brain’s cognitive functions. Aimed at those with declining health, such as the elderly, or those with mentally demanding professions, nootropics have only grown in popularity over the years. The perceived benefits claimed by many nootropic brands can include anything from memory enhancement and positive mood boost to an increase in motivation and energy.

Mind Lab Pro

One of the few Universal Nootropics currently available, Mind Lab Pro’s nootropic supplement aims to enhance several cognitive pathways that boost an individual’s overall mental function. We consider it as the best nootropic for energy and motivation. Using 11 clinically tested and research-backed supplements, Mind Lab Pro provides an all-around brain booster that is safe and effective.

Benefits

Mind Lab Pro’s Universal Nootropic optimizes brain function to help individuals reach their peak cognitive performance ability. Combining their 11 different, brain-boosting ingredients provides both an immediate and long-term boost in both the health and function of the brain. Other benefits of the Universal Nootropic include:

  • Energize mental abilities in a similar way that stimulants do, without the crash, by boosting brain cell formation with Citicoline
  • Enhance cognitive processing under stress with Bacopa Monnieri.
  • Increase mental clarity, focus, and energy with Maritime Pine Bark Extract.

Recommended Dosage

The standard recommended dosage of the Universal Nootropic is 1 to 2 capsules in the morning or early afternoon. As the body acclimates to the supplement, the dosage can be increased to 4 capsules a day, but no more than that is advised.

Overall, the best nootropic for energy and motivation is the one that works best for the individual. There is no one-size-fits-all in the world of supplements as every body metabolizes the ingredients differently, and the only way to truly know which one will work the best is through trial and error.

While there are many nootropics, and many with similar benefits, some tend to stand out more than others. For increased energy and motivation, the following nootropics are the highest-rated and considered the best overall.

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NooCube

Developed by neuroscientists, NooCube uses an array of natural, clinically tested ingredients to boost the brain’s cognitive function. Its ingredients include seven different herbal supplements and amino acids that support healthy communication between brain cells.

Benefits

Each of the seven different ingredients included in NooCube’s nootropic formula has been put through rigorous testing for both safety and effectiveness. All have exhibited positive effects in scientific research trials in treating a host of cognitive ailments from memory loss to cell damage. The combination of nootropics that are included in the NooCube’s supplement provides the user with a variety of benefits, including:

  • Increasing mental energy and the ability to focus with the amino acid L-tyrosine.
  • Improving the blood flow to the brain in order to feel more alert and energized with Oat Straw.
  • Enhancing an individual’s overall mood to relaxed alertness with L-theanine.

Recommended Dosage

The best way to take this combined nootropic is with the first meal of the day. It is recommended to start out taking just two capsules, and after the body has gotten used to the supplement, the dosage can be increased to three or four capsules a day.

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Performance Lab – Energy

The Performance Lab’s Energy supplement combines the brain-boosting power of a nootropic with the energizing effects of a stimulant, all without the crash associated with the typical caffeine-style stims. It includes a combination of five amino acids and antioxidants that work together to provide the body with a sustainable source of energy.

Benefits

The Energy supplement from Performance Lab works by enhancing the mitochondrial function in cells to give the body clear, clean energy to keep an individual going for hours without any crashing. Some of the potential benefits of the supplement include:

  • Boost the production of cell energy with Acetyl-L-Carnitine.
  • Enhances the amount of energy obtained from food and how quickly it can be used in the body with the vitamin CoQ10
  • Enhances an individual’s metabolism and allowing it to produce more energy with black pepper extract.

Recommended Dosage

The Performance Lab’s Energy supplement can be taken once after waking and once midday. An individual can take 1 to 2 capsules each time, with no more than four taken a day. It is recommended, for the best results, to take the supplement daily.

References

  1. https://pubmed.ncbi.nlm.nih.gov/26618715/
  2. https://www.psychologytoday.com/us/blog/experience-engineering/202006/study-finds-ubiquinol-reduces-fatigue-in-healthy-people

25Dec

The 3 Best Nootropics For Productivity

Nootropics use synthetic or natural supplements to enhance cognitive abilities in individuals. Also called “smart drugs,” these supplements are used to boost mental performance in relation to memory, focus, motivation, and energy, just to name a few. Some nootropics, such as caffeine, have been used for decades to improve concentration and help propel individuals through their workday.

Improved productivity is one of the most sought after benefits of nootropic users. Finding a supplement that will help propel an individual through their day and help them complete their tasks efficiently is vital to both working professionals and students alike.

Mind Lab Pro

Mind Lab Pro’s is considered one of the only universal nootropics currently on the market and is the best nootropic for productivity. It contains 11 different nootropics that optimize the whole brain for both immediate cognitive improvement and long-term health.

Mind lab pro

Benefits

While it may seem like 11 different cognition boosting ingredients are a lot for one supplement, they have been thoroughly researched and fine-tuned to provide the best mental enhancement with the least dosage. They do this by targeting the four core areas of cognitive health, which are memory, structure, mindset, and performance. Some of the nootropic ingredients include,
– Lion’s Mane Mushroom helps to boost memory by stimulating brain cell growth and increases the speed at which the brain processes information, leading to better focus.
– Rhodiola improves mental performance and helps to decrease mental fatigue.
– B12 helps to reduce neuron loss in the brain that can lead to memory problems.

Recommended Dosage

It is advised, for a beginner, to take a standard dosage of 2 capsules daily, either in the morning or directly before a mentally taxing situation, such as a test or work deadline. After the body has gotten used to the supplement, individuals can bring on benefits quicker by taking four capsules a day, effectively doubling their dose.

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Noocube

NooCube’s Brain Productivity supplement is a combination of seven nootropics that provide an individual with enhanced focus, concentration, and mental speed. It was developed by neuroscientists and rigorously tested for its effectiveness and safety.

Noocube

Benefits

This nootropic gives individuals a steady, calm boost of mental awareness and focus that can make them more efficient and productive in their day to day lives. Some of these beneficial ingredients include:


Alpha GPC works to increase chemicals in the brain that can lead to better concentration and mental focus.
– Oat Straw helps to increase blood flow to the brain and enhance overall mental alertness.
– Bacopa improves mental performance and cognitive function by increasing neuron communications.

Recommended Dosage

While up to four capsules can be taken daily, it is highly advised to start with only two at first in order to see how the body reacts to it. The capsules should be taken with the first meal of the day to better absorb into the body.

Overall, choosing the right nootropic is the one that best works with the body chemistry of the individual that is taking it, as all bodies absorb and react to chemicals differently.

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Performance Lab Mind

Performance Lab’s Mind supplement is geared towards improving the brain’s overall performance while also helping it to recover from stress, burnout, and fatigue. It is one of the simplest combination nootropics as it contains only four separate cognitive supplements for zeroed in benefits.

Benefits

While the Mind supplement from Performance Lab only has four ingredients, their potency provides focused cognitive enhancement that boosts an individual’s focus, memory, and concentration, all while improving their overall brain health. The ingredients in the Mind supplement include:

– Cognizin, or Citicoline, one of the core ingredients of the supplement, and it helps to improve brain function and overall memory.
– Sharp-PS Green improves and preserves brain function and attention while also increasing the development of brain cells.
– L-Tyrosine helps the mind with increased alertness and improved focus during stressful situations.
– Maritime Pine Bark Extract helps to preserve cognitive abilities in older individuals and provides support to the memory.

Recommended Dosage

Performance Lab’s Mind supplement is designed for daily use and is easy to swallow and digest due to its capsules that are 100% plant-based. It is recommended to take 1 to 2 capsules a day, preferably in the morning during the first meal of the day. As the supplement is fat-soluble, taking it with a fat of some sort such as milk or MCT oil will allow for the best absorption.

References

  1. https://www.alzdiscovery.org/cognitive-vitality/ratings/citicoline
  2. https://selfhacked.com/blog/pycnogenol-pine-bark-extract-health-benefits/
  3. https://www.healthline.com/nutrition/bacopa-monnieri-benefits
23Dec

Fasoracetam: Usage, Dosage and Benefits

Fasoracetam is a “racetam” drug believed to have some cognitive boosting properties. It’s said to be a nootropic that can enhance different cognitive functions and reverse some of the symptoms of neurodegenerative disorders like Alzheimer’s Disease.

Fasoracetam was developed by Nippon Shinyaku in the 1990s. The Japanese company developed the drug with the intention of treating vascular dementia, but they abandoned their research before they could complete phase 3 clinical trials. Several years later, NeuroFix bought the clinical data and restarted the trials. Today, Fasoracetam is under Aevi Genomic Medicine, which acquired the company NeuroFix. They continue to investigate the effects of Fasoracetam on anxiety, autism, ADHD, and other conditions. Most of these trials are in their early stages, so there’s still no clear evidence pinpointing the efficacy of the drug.

Fasoracetam bottle

Nonetheless, the little data available on the nootropic is very promising. Several animal studies have demonstrated some of the potential uses and benefits of this “smart drug.” There’s also a good number of people who are already taking the drug despite the lack of exhaustive clinical trials. Some of the users are reporting a few improvements in cognition and mood. Sadly, it’s hard to tell what the short and long-term effects of the drug could be without thorough clinical trials.

The nootropicis also known as NFC 1, NS-105, MDGN-001, and LAM 105. It is not approved by the FDA, but it’s available on the market as a research chemical.

Working Mechanism

Preliminary data suggests several working mechanisms of Fasoracetam. According to some trials, Fasoracetam modulates the production of key neurotransmitters to enhance your brain functions. For instance, this animal study reported Fasoracetam increased the uptake of choline. Choline is a precursor to acetylcholine. Acetylcholine, on the other hand, is a neurotransmitter that aids learning, memory, and other brain functions. Therefore, an increase in choline uptake results in a boost in acetylcholine in the cerebral cortex, and this should improve your cognition.

Fasoracetam also activates metabotropic glutamate receptors or mGURs. This restores a healthy balance in the glutamate system, which means Fasoracetam may be beneficial in treating conditions such as ADHD, anxiety, and some mental disorders.

According to some in vitro data, Fasoracetam may also increase GABA or gamma-aminobutyric acid receptors in the cortex. This increases GABA levels in the brain and central nervous system, which may reduce anxiety and depression.

Uses and Benefits

Based on the limited data available at the moment, Fasoracetam may be useful for:

  • Improving Memory

Fasoracetam can prevent memory loss and boost memory formation, storage, and retrieval. This has been observed in several animal studies involving both healthy and unhealthy rats. For instance, in this trial involving rats treated with baclofen, Fasoracetam helped fight memory loss issues.

Anecdotal evidence also shows some improvements in memory and overall cognition. This may be explained by the increase in acetylcholine induced by the drug. The nootropic also prevents activation of GABA-B receptors, which are known to impair memory and other brain functions.

  • Relieving Anxiety and Depression

Psychiatric conditions like depression and anxiety are closely linked to unhealthy GABA and glutamate levels. Fasoracetam modulates both of these neurotransmitters to improve your mood, motivation, and a general feeling of well-being.

In this trial investigating the impact of the nootropic on learned helplessness in rats, the researchers observed powerful antidepressant effects.

Some users also report feeling calmer and more relaxed after taking the nootropic.

Additional human studies are necessary to fully understand the effects of NS105 on anxiety and depression.

  • Treating ADHD

In this trial, 30 adolescents with ADHD were placed under the nootropic to investigate the potential efficacy of the drug. The subjects were aged between 12 and 17 years, and they also had glutamatergic gene network variants affecting their mGLUr neurotransmitter signaling. At the end of the study period, the researchers noted a significant improvement in several tests. There was also no difference between the group under treatment and the placebo in terms of adverse events.

Side Effects

The nootropic is generally well tolerated when used correctly, but it still has the potential to cause adverse reactions, especially when taken in high dosages. Due to the lack of exhaustive clinical trials, Fasoracetam may pose some serious long-term risks that remain unknown.

Some of the side effects reported by a few users are fatigue, headaches, and digestive discomfort. The drug can also slow your heart rate when taken in extremely high dosages.

Stick to the recommended dosages at all times to reduce the risk of developing adverse reactions. Anyone with an existing medical condition should consult a physician before taking the nootropic. Pregnant and nursing mothers should avoid it as well.

Dosage

There are no official Fasoracetam dosages. The guideline available at the moment is based on anecdotal experience and a few of the studies done so far. Based on this data, the nootropic may be beneficial and safe in oral dosages of between 100 and 800mg. You should start low and increase the dosage if necessary.

Fasoracetam can also be used sublingually. This method requires lower dosages since most of the drug ends up in your bloodstream pretty fast. Sublingual administration exposes users to the somewhat unpleasant taste of the drug.

You can take the nootropic with or without food.

Fasoracetam is sometimes combined with other nootropics to improve the results or minimize the risk of side effects. It can be stacked with a choline source like CDP Choline.

Final Thoughts

Human trials on Fasoracetam may be limited, but it is clear that the drug has so much potential. Numerous human studies have shown its ability to treat conditions like ADHD and anxiety. Some users also report improved mood, motivation, and calmness. Animal trials also reported memory enhancement. Even more interesting is that most trials did not report any severe adverse events. Therefore, the nootropic can be very helpful, but it should be used carefully.

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References

  1. https://www.nature.com/articles/s41467-017-02244-2
  2. https://www.researchgate.net/publication/322527361_Fasoracetam_in_adolescents_with_ADHD_and_glutamatergic_gene_network_variants_disrupting_mGluR_neurotransmitter_signaling
  3. https://www.unboundmedicine.com/medline/citation/28109793/A_study_of_Fasoracetam’s_solid_state_forms:_A_potential_anti-Alzheimer_pharmaceutical.
23Dec

Sunifiram: Usage, Benefits & Dosage

Sunifiram or DM-235 is a relatively new research chemical categorized as a nootropic or cognitive enhancing drug. It is derived from Piracetam, another very popular nootropic. Unlike racetams, Sunifiram is more potent, with data showing that it is 1000 times more powerful than Piracetam!

According to the scientific evidence available at the moment, it can boost memory, learning ability, and mood. It may also boost energy levels.

Sunifiram was developed in 2000 by scientists from the University of Firenze, Italy. It was initially developed for treating the cognitive decline symptoms of Alzheimer’s disease. The research was sadly abandoned, so they didn’t publish any clinical data.

Today, Sunifiram is available as a research chemical. The FDA has not approved the use of the drug for any medicinal uses. They also do not regulate it, so people can buy from online stores as a dietary supplement.

Mechanism of Action

The mechanism of action of Sunifiram is not 100% understood. Based on its striking similarities to Piracetam, some studies suggest that it affects the brain the same way Piracetam does. No reliable human trials support the claim, though.

Based on the limited research, scientists have put across several possible mechanisms of action explaining how the nootropic can be beneficial.

First, animal studies have reported that Sunifiram improves acetylcholine activities in the brain. In a study done on mice, the drug fought scopolamine, a compound that inhibits the release of acetylcholine. The neurotransmitter acetylcholine plays a vital role in learning, memory, and other brain functions. This would explain how this nootropic is believed to be an effective nootropic as well as a treatment for cognitive decline associated with Alzheimer’s disease.

It’s also possible that Sunifiram improves learning and cognition by activating the AMPA-mediated neurotransmission system.

According to another study done on mice, Sunifiram stimulated the release of glutamate and activated the glutamate receptors. This boosts synaptic plasticity, which is essential for learning and other cognitive functions.

Uses and Benefits

Most of the uses and benefits of Sunifiram are mostly theoretical. The drug is relatively new in the scene, and it hasn’t been subjected to any reliable human trials. The uses discussed below are based on the preliminary data from limited animal studies.

  • Improves Memory and Learning

Multiple animal studies have reported Sunifiram’s ability to improve memory and learning. In some of these studies, the researchers looked at the impact of Sunifiram on mice with amnesia induced by drugs like baclofen, clonidine, and scopolamine. The researchers observed significant improvements suggesting Sunifiram may be effective in reversing memory loss issues caused by certain medications. While the results are very promising, they are far from definitive because they are limited to animal subjects. Also, the study involved subjects that had been treated with memory-impairing drugs. It’s impossible to tell whether they can boost memory in healthy individuals.

Since this nootropic can influence acetylcholine activities, it’s also possible that it can improve learning. A few studies have suggested this usage, but they were all done on mice.

Large-scale clinical trials are necessary to understand the efficacy and safety of Sunifiram fully.

  • May Reduce Pain Sensitivity

In a trial involving rats subjected to heat-related pain, the researchers reported that the mice treated with Sunifiram had a better response to the pain.

Other than the above benefits, a few trials also claim the nootropic can increase sex drive, improve mood, and boost energy levels.

The biggest drawback with Sunifiram is the lack of extensive clinical studies, meaning we cannot say tell with absolute certainty whether the drug is as beneficial as claimed or not.

Side Effects

Again, due to the lack of sufficient clinical trials, the safety of Sunifiram remains mostly unknown. Another concern is its potency, which is reported to be 1000 times higher than Piracetam’s. Being such a powerful compound, Sunifiram may induce some serious adverse events if used recklessly.

So far, the only adverse reactions reported are headaches, increased perspiration, high body temperature, nasal stuffiness, insomnia, restlessness, forgetfulness, mental sluggishness or brain fog, anxiety, and increased sensitivity to audio and visual stimulation.

The smart thing to do is avoid using Sunifiram until we have enough scientific evidence documenting its benefits and safety. However, if you still want to use it, you should do so under the guidance of a licensed physician. Make sure to follow the recommended dosage at all times. You should also avoid using it for a prolonged period.

Consult a physician before taking the supplement if you have an existing medical condition. Pregnant and nursing mothers should avoid the drug.

Dosage

There are no official dosages of this drug. The dosage guideline available at the moment is based on anecdotal experiences. Given the extreme potency of the drug, users require only small doses to feel its effects.

Most people experimenting with the drug use it in dosages of between 5 and 10mg taken two or three times per day.

Using it in high doses or for too long can lead to tolerance so, it should be used in short cycles with breaks in between.

Can You Stack Sunifiram with Other Nootropics?

The practice of stacking multiple nootropics to boost the results has grown very popular in the last few years. Most of these stacks work quite well without causing any adverse reactions. This is especially common in people who already have vast experience with these drugs.

Theoretically, the product can also be stacked with other nootropics, but that’ll be ill-advised. There is so much about this drug that we do not know. This includes drug interactions and possible long-term side effects. It’s also a very powerful compound. For such reasons, it’s wiser to avoid combining Sunifiram with any other dietary supplements until more clinical trials on its effects and safety are published.

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References

  1. https://examine.com/supplements/sunifiram/
  2. https://www.sciencedirect.com/science/article/abs/pii/S096808960900830X
  3. https://www.unboundmedicine.com/medline/citation/16834757/Pharmacological_characterization_of_DM232__unifiram__and_DM235__sunifiram__new_potent_cognition_enhancers_
21Dec

Huperzine A: Usage, Benefits & Dosage

Huperzine A is a dietary supplement extracted from a Chinese plant called Huperzia Serrata or Chinese club moss. Chinese club moss is a traditional medicine used to reduce inflammation, sharpen memory, and deliver other health benefits.

It captured the attention of Alzheimer’s research scientists who reported that the compound could reverse the cognitive decline issues associated with neurodegenerative disorders like dementia. According to some preliminary data, Huperzine A can inhibit the activities of cholinesterase, an enzyme that breaks down the vital neurotransmitter acetylcholine. By combating this enzyme, it effectively promotes the actions of acetylcholine to improve memory, attention, and learning ability.

Huperzine A jar

There have also been reports that Huperzine A could be an effective memory booster in healthy individuals. That’s why the drug is also sold as a nootropic. However, the scientific evidence backing its effectiveness for this purpose is very limited.

It is also known by the names HupA, Huperzine, Selagine, and Huperzina A.

Uses and Benefits of Huperzine A

According to the limited scientific data available at the moment, it may be beneficial for:

  • Alzheimer’s Disease

Huperzine A is believed to be a potential treatment for the symptoms of Alzheimer’s disease and other forms of dementia. Other than treating the condition, it may also help reduce the risk of developing Alzheimer’s in people who are already at a predisposed risk.

Huperzine A might be useful for this purpose due to its impact on the learning neurotransmitter acetylcholine. The compound reduces the activities of the chemical Cholinesterase. This increases the levels of acetylcholine hence improving key cognitive functions. In doing so, Huperzine A reverses Alzheimer’s symptoms such as memory loss, poor concentration, and learning impairment.

The biggest challenge with Huperzine A is the lack of large-scale human trials to support its efficacy. There have been a few human studies involving subjects with Alzheimer’s disease, but these studies are not of the highest quality. For instance, this trial involving 454 Alzheimer’s patients reported improved cognitive functions and functional performance without any adverse events, but the study had several shortcomings. In the end, the researchers recommended more rigorous and randomized trials for more reliable results.

A few studies have also produced contradicting results showing the product did not have a significant impact on the cognitive functions of Alzheimer’s patients.

It’s clear that the only way to know how beneficial Huperzine A might be for Alzheimer’s patients is through thorough clinical trials. They will also help us understand the safety profile of the drug better. Hopefully, we’ll see more of these trials in the near future.

  • Memory Enhancement

Huperzine A may boost memory and cognition in healthy individuals, including students and professionals. It can also promote normal cognitive functions in aging people, a population where age-related cognitive decline is very common.

Of course, these claims stem from the reported Huperzine A’s mechanism of action that involves increasing the learning neurotransmitter acetylcholine. The only problem is that there haven’t been many clinical trials investigating this effect. Only one trial has reported the memory enhancement abilities of Huperzine A in healthy individuals. The trial had a very small sample size of just 34 adolescent students.

In addition to the above uses, Huperzine A is also purported to be beneficial for:

  • Treating psychiatric disorders like depression and Schizophrenia
  • Increasing mental alertness and energy
  • Improving neuroprotection
  • Fighting cocaine use disorder
  • Fighting glutamate toxicity
  • Treating myasthenia gravis. An autoimmune disorder causing rapid fatigue and weakness of muscles

Side Effects

Huperzine A is generally safe and well-tolerated when taken appropriately.

In some rare cases, this nootropic can produce side effects like blurred vision, diarrhea, vomiting, constipation, dry mouth, sweating, nausea, slurred speech, restlessness, dizziness, high blood pressure, slowed heart rate, sleep disturbance, and loss of appetite. The safety profile of Huperzine A is not known 100%, but reports show the risk of adverse reactions increase when the drug is abused. Long-term effects of the drug are also not known.

As a safety precaution, pregnant and breastfeeding women should avoid this drug. Individuals with existing medical conditions like seizure disorder, stomach ulcers, and cardiovascular diseases are also advised against using Huperzine A. In summary, do not use this drug without a doctor’s approval if you have any medical condition.

Dosage

Huperzine A is usually administered orally, but you can also use it through injections. There are no official dosages that are guaranteed to be safe and effective for everyone. Based on anecdotal experiences and a few of the available studies, a dosage of around 100mcg taken twice daily is said to be most effective for memory enhancement. For Alzheimer’s disease, dosages of between 300mcg and 500mcg taken twice per day are recommended.

To treat Myasthenia Gravis, Huperzine A is administered through intramuscular injections. The dosages used here are typically low. You should only use Huperzine A for this purpose with a doctor’s permission and supervision.

Final Thoughts

This product is a drug with so much potential but not enough clinical data backing it. For that reason, we’ll encourage you to speak to a licensed physician about a possible alternative, especially if you are looking to treat a medical condition like Alzheimer’s disease or Myasthenia Gravis.

For the people who want to use it for its potential nootropic benefits, make sure to take it in the right dosages and for short-term. Stop using the drug if you experience any severe side effects.

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References

  1. https://www.alzforum.org/therapeutics/huperzine
  2. https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/expert-answers/huperzine-a/faq-20058259
  3. https://www.sciencedirect.com/topics/neuroscience/huperzine-a