Last updated on July 20th, 2021 at 11:47 pm

What is Ostarine?

Ostarine is an oral selective androgen receptor modulator (SARM), also known as Enobosarm or MK-2866 in short. The SARM was originally under development by Merck & Company. In 1997, GTx Incorporated was formed, and soon afterward, they acquired and licensed the rights to MK-2866. Although GTx Inc. owns the rights of the drug, the compound was developed by several scientists, including James T. Dalton and Duane D. Miller of Ohio State University and the University of Tennessee, respectively.

Since its development, Ostarine has gone through numerous trials. By 2013, GTx Inc. had already spent approximately $35 million on Ostarine. The drug had gone through two Phase II trials, one in 2007 and the other in 2011.

In the 2011 double-blind placebo trial, Enobosarm was administered in postmenopausal women and elderly men. One of the goals of the trial was to investigate the effects of Enobosarm on cachexia (muscle wasting). At the end of the study, the scientists observed statistically significant increments in total body mass. The effect was dose-dependent. Moreover, they noticed an improvement in physical functions and insulin resistance. Another interesting observation was the lack of significant differences in adverse events between the different treatment groups.

In conclusion, the 2011 Gtx Inc. trial on MK2866 showed the SARM could prevent and treat cachexia linked to chronic conditions like cancer.

Ostarine has been shown to help people that suffer from a muscular disease, like osteoporosis. For personal, recreational use, Ostarine can improve:

  • muscle growth,
  •  fat loss,
  • and bone density.

As you use Ostarine, the medication transforms fat into muscle, so you can slim down and get stronger at the same time.

Current research has found that Ostarine can increase bone density. It might be a way to prevent bone fractures, especially for people that are prone to getting fractures.


Outside the medical field, Ostarine is popularly used by athletes to boost muscle growth and athletic performance. Some of the Ostarine benefits enjoyed by these users are:

Muscle Growth

In the past clinical studies, scientists didn’t just observe Ostarine’s ability to prevent muscle wasting, but they also noticed that the drug boosted lean muscle mass. The results were really impressive, especially when the drug was supported with the right diet and exercise.

Anecdotal reports also prove that Ostarine is effective for muscle growth. Professional bodybuilders include Ostarine in their workout regimen, where it delivers several pounds of lean muscle mass in just one cycle. With the correct dosage, diet, and workout routine, Ostarine can deliver up to 15 pounds of muscle mass!

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Not everyone can spend endless hours in the gym, though, so what if you take Ostarine in small doses with an average workout routine? Well, even beginners can gain between 5 and 8 pounds of lean mass within a few weeks, which is quite good. However, you are advised to eat right and train properly for maximum results.

While on the subject of beginners, it is worth pointing out that Ostarine is one of the best SARMs for beginners. The drug is relatively mild, so it’s usually very well tolerated by the body. It doesn’t feel overbearing, so the risk of severe adverse reactions is significantly lower as compared to other more potent SARMs.

Fat Loss

Ostarine is widely used in cutting cycles as part of a stack. In such stacks, Ostarine supports fat loss while preserving lean muscle mass and maintaining steady energy levels.

Ostarine can also burn some fat when used on its own. The fat loss is not very drastic, but it’s still good enough to promote muscle definition and improve your overall physique. The SARM achieves this by stimulating your body to turn to fatty acids for fuel. It also targets the androgen receptors in the adipose tissue, increasing fat metabolism.

The increase in anabolic activities that promote muscle growth also helps in breaking down fat.

Increased Stamina

There is a reason many athletes, including professional ones, turn to SARMs. These drugs significantly increase energy, strength, stamina, and endurance. That’s also why they are banned by the World Anti-Doping Agency.

Just like other SARMs, Ostarine is very good at increasing stamina and energy levels. You could go hard on the gym for hours before your muscles and body start showing signs of fatigue.

MK2866 achieves this by breaking down calories and fats to fuel your body. It also increases nitrogen retention, which supports both muscle strength and growth.

Improved stamina significantly boosts the other benefits of Ostarine. For instance, more energy and strength allow you to train for longer, promoting muscle growth and fat loss.

Enhanced Bone Density

MK-2866 was initially developed to treat osteoporosis, a condition characterized by weak and brittle bones. With osteoporosis, bone regeneration is never efficient enough to keep up with ongoing old bone removal.

Multiple studies proved that MK-2866 could prevent this condition. And it goes further to increase bone mineral density resulting in strong and healthy bones.

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Stronger bones protect Ostarine users against fractures and injuries, which are very common among athletes.

Promotes Healing and Recovery

Enobosarm supports the healing of muscles and joints. With maximum muscle regeneration, Ostarine speeds up the healing of muscle-related injuries.

Individuals with bone injuries also find MK2866 very useful since it increases bone regeneration.

In addition to healing, Ostarine MK2866 promotes muscle recovery. Issues of prolonged muscle soreness and inflammation are very rare among SARM users.

With proper use, Ostarine will help you maintain consistent strenuous training with minimal time wasted on the sidelines. Neither injuries nor muscle soreness will stop you from dominating your workouts with high-intensity momentum.

Improved Heart Health

Ostarine boosts heart health in several ways. First, it reduces the bad LDL cholesterol levels. This reduces the risk of high blood pressure, stroke, and heart attack. Some data shows it can increase HDL or “good” cholesterol as well. 

MK2866 also increases insulin resistance and lowers blood glucose levels.

Side effects

Although there are some short-term side effects while you take Ostarine, most users reported having little to none. The most common side effects while taking the medication is:

  • A decrease in HDL cholesterol levels,
  • Back acne outbreaks,
  • Constipation,
  • Joint pain,
  • Headaches,
  • Increased appetite,
  • Drinking alcohol can strain your liver and may cause liver issues.

It is recommended that you do not exceed 25 mg a day because the long-term side effects have not been observed yet.

Do not let this sway you, most of the studies on this medication has concluded that just taking a little bit every day, like 3 mg, can still lead to a significant amount of muscle gain.


Depending on the result you want and the amount your body tolerates, Ostarine should be taken in 8 or 12 week cycles. The most recommended dose is a daily 15 mg for 8 weeks.

For the best, safest results, a cycling schedule should last for at least 16 weeks, and could look like:

  • First 8 weeks: 15 mg daily,
  • Next 4 weeks: Post cycle Therapy,
  • Last 4 weeks of one cycle: Do not take any SARMs,
  • Repeat, until you get the desired result.

If you need more time than 4 weeks to have a break from Ostarine, you can take as much time as you need to rest. Taking more than 4 weeks to rest will help your body retain an equilibrium. You should always give yourself a minimum of 4 weeks of rest, at the end of each cycle.


For the quickest results, you can use a stacking method. Stacking SARMs consists of using a combination of medication for the most effective results.

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This method is best recommended for bodybuilders. But, when first starting this drug, you should use the basic dosage instructions above. This allows time for your body to get comfortable with the medication.

The benefits of stacking are:

  • Increases stamina and endurance,
  • Speeds up lean muscle growth,
  • Accelerates muscle recovery rate,
  • Burns that pesky fat that just won’t give up,
  • Overall quicker results.

There are two reasons to use this stacking method, to cut down fat, cutting, or to build muscle, bulking.

For cutting, you lower your calorie intake. Ostarine combats this excellently, so you do not have to worry about losing muscle mass because of a lower calorie diet.

A good combination is Ostarine and Cardarine. Ostarine provides the security of not losing muscle mass while dieting, and Cardarine enhances cardio performance. With an increase in cardio and fewer calories, you can burn away your fat while not losing any muscle mass.

A triple stack incorporates three SARMs, Ostarine, Cardarine, and Andarine. This combination is extremely strong. When used, you will receive the most efficient results, but you should do it cautiously. Never start using the triple stack if you have never used any SARMs.

Bulking is another way to use stacking, and it greatly increases the speed of the muscle-building process. A good SARM that works well with Ostarine is Ligandol.

The bulking process is similar to the stacking process, except for the first week, you should take 10mg of Ostarine, then 20mg for the rest of the weeks.

When doing any form of stacking, you should stack for 8 weeks, then switch to post cycle therapy for the next 4.

Post Cycle Therapy

Post cycle therapy (PCT) is a vital step to using SARMs safely and should be used in every cycle for 4 weeks. This step should never be skipped, no matter what method you are using. The main reason for PCT is to keep your hormone levels normal. The easiest and most common way is taking an over-the-counter testosterone booster for at least 4 weeks.It is recommended that you monitor your hormones for safety purposes. The most accessible and reliable way is getting your blood work done.


To sum it up, Ostarine is extremely beneficial to everyone. It’s not just good for muscle building and athletic performance, but it can also improve your cardiovascular health. MK2866 is also one of the few decent options for beginners who need a friendly SARM to kick start their bodybuilding journey. Still, it’s not a magic bullet, so you’ll need to work hard to get maximum gains.

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