S23 is a non-steroidal Selective Androgen Receptor Modulator (SARM) from GTx Inc. SARMs are a new class of drugs that act like testosterone targeting certain receptors in the body located in muscle and bone tissues. Studies suggest these drugs can be effective for treating issues like muscle wasting and osteoporosis. However, the clinical research on these drugs is very lacking.
S23 is a modified version of another SARM molecule known as C6. Just like other SARMs, the drug is not very well-studied. Still, there is a lot of promising data coming from animal studies. S23 is currently under investigation as a potential male contraceptive.
According to the available studies, this SARM induced infertility in all the rats it was administered to. The effect was dose-dependent and temporary, meaning the mice regained their fertility immediately after the treatment was stopped. This makes S23 a potential oral male contraceptive.
According to the research, the drug suppresses serum concentration of luteinizing hormone and follicle-stimulating hormone to produce biphasic effects on spermatogenesis. Additional clinical trials are still necessary to determine how effective and safe S23 is as a contraceptive.
The above study also produced other desirable effects. For instance, scientists observed a stronger affinity to androgen receptors as compared to other SARMs like Andarine. It also has an ideal anabolic-androgenic ratio allowing it to produce a good number of positive effects without any severe complications. One of those effects was increasing bone mineral density and lean muscle mass.
Therefore, while S23 may be effective as a male birth control pill, it can also be used for other purposes, especially among patients with chronic conditions that lead to muscle wasting. The fitness industry can also benefit hugely from this drug.
What are the benefits
The S23 SARM comes with a long list of excellent benefits. While most people focus mainly on the ones that relate to their fitness goals, the fact is that this SARM also offers benefits that may go beyond a person’s fitness goals.
In addition to birth control, this SARM is beneficial in the following ways:
- Boosting Bone Mineral Density
Testosterone and estrogen are vital for healthy bones. Unfortunately, sex hormones can reduce due to various reasons, e.g., poor lifestyle, aging, use of certain medications, and presence of some chronic conditions. As the hormones reduce, your bones are left susceptible to conditions such as osteoporosis.
All SARMs, including S23, are effective for preventing bone diseases like osteoporosis. Some SARMs were actually developed with this particular purpose in mind. The drugs promote bone health in two main ways. First, they interact with the androgen receptors in the bones and activate bone-building cells. This boosts bone mineral density hence increasing the strength and overall health of your bones.
The SARM also increases muscle mass and strength, and as multiple studies report, these two effects result in stronger bones.
- Increasing Lean Muscle Mass
Building lean muscle mass is one of the key reasons behind SARMs’ popularity in the bodybuilding world. These drugs target androgen receptors in the muscle tissues with a similar effect as testosterone. They increase nitrogen retention and boost protein synthesis resulting in bigger and faster muscle growth.
S23 users report witnessing more than 10 pounds of muscle growth in just a single cycle! However, you should know that these results are not always consistent. Other factors like your specific training routine and diet will influence the rate and size of your gains. In any case, the use of this SARM produces better results than natural bodybuilding.
- Promoting Fat Loss
S23 promotes fat loss in several ways. By boosting muscle growth, it puts your body in a highly anabolic state. This increases your metabolic rate and, by extension, the breakdown of fatty acids in different parts of the body.
It also triggers your system to target adipose as a source of fuel. Not only does this promote fat loss, but it also increases your athletic performance.
This selective androgen receptor modulator’s ability to induce fat loss has made it a great choice for athletes who want to burn the extra fat covering their muscles. In simpler words, it helps them get the much-desired shredded look. And unlike a typical fat burner, the SARM will also be adding a few pounds of lean mass during the process.
- Enhancing Sex Drive in Women
One of the most fascinating observations in the studies involving S23 is its effects on women’s libido.
Preclinical studies show S23 can treat hypoactive sexual desire disorder (HSDD) without putting the users at severe risk. In this trial, the SARM was administered in postmenopausal rats, and the researchers observed a positive effect in the regulation of female libido. Additionally, the drugs did not alter the uterine lining and the overall size of the uterus.
These results are very promising, but women are encouraged to discuss the efficacy of using S23 for libido enhancement and possible alternatives with a licensed physician before taking the drug.
- Improving Recovery
Selective androgen receptor modulators are popular for speeding recovery after intensive training sessions. This eventually increases the number of hours you can spend in the gym hence boosting your overall fitness progress.
Additionally, faster recovery makes it easier for you to maintain a healthy balance between your fitness and professional life if bodybuilding is not your primary lifestyle. In other words, it allows you to train all you want and still have enough energy and motivation to clock in at your day job and have fun with your family.
It’s clear that S23 is a highly beneficial selective androgen receptor modulator. Its potency in enhancing muscle growth and fat loss has been compared to anabolic steroids, but it has a safer profile.
Keep in mind that S23 is still a research drug under investigation. Therefore, it’s advisable to approach it with caution since there are no reliable clinical trials to show its possible long-term effects. And if you are already using it, watch your dosage closely and support it with the correct diet and training routine for the best outcome.
The SARM is generally safe, and plenty of satisfied users are living proof of that. Still, to make a well-informed decision, there are a few things you need to know about it. These include:
- Increased acne and hair loss Unfortunately, users have reported an increase in acne on their faces and backs as a result of cycling S23. On top of that, some have also experienced increased hair loss which they point to the the product as its cause.
- Unexpected aggression Some users have also shared that they’ve felt an increased sense of aggression, which is something to be cautious about when using S23.
- Suppression of testosterone Testosterone levels are also at risk of dropping. One step that some users have taken is to monitor their T levels more actively when on S23.
Generally speaking, here are some facts to keep in mind about the S23 in its current form:
- Its long-term effects are still unknown The fact of the matter is that nobody knows what the long-term side effects of it might be. While there are plenty of promising studies supporting the benefits, most of what we know is anecdotal from people who have used it before. Remember: not everybody responds the same way physically to things like SARMs.
- It is still not approved by the FDA The Food and Drug Administration (FDA) has not approved the S23 SARM. That might change in the future, but the fact is that it does not have that approval at this point in time.
- It requires more clinical studies The bottom line is that the SARM requires more clinical studies, especially human studies. Animal studies are promising, but for there to be absolute certainty on the positive and negative effects of SARM, its developers need to perform more human clinical studies on it.
Dosage and Cycles
If you’ve decided to use the S23 , here’s one more thing you need to know: the lack of human clinical studies means that no one has discovered the ‘ideal’ dosage for humans yet. Based on what we know from past users, taking 10-25 mg of the S23 SARM is what most users consider to be the best practice for now.
To be precise, newbies are best off starting with 10 mg per day, before graduating to 15 mg/day for intermediates, and eventually 25 mg for more advanced users.
It’s best not to exceed that daily amount, or to do so at your own risk.