08Dec

DMAA: Usage, Side Effects and Dosage

Methylhexanamine, or DMAA, is a synthetic drug created in a lab, originally used as a nasal decongestant via a nasal spray. It is an amphetamine derivative that is illegal in several countries. It is currently sold as a dietary supplement for increased energy, weight loss, and athletic performance. Due to safety concerns, the FDA is actively working on removing the commercial availability of dietary supplements containing DMAA.

DMAA

Medical History

Created by Eli Lilly and Company in 1948 as a nasal decongestant, DMAA was used for many years until the company voluntarily recalled it in the 1970s. In 2006, it began to be used as a stimulate in various dietary supplements. Many dietary supplement manufacturers claimed that it was a naturally derived compound from the geranium plant and perfectly safe to use. Over time the drug’s safety was put into question due to the adverse effects it was giving users and the five deaths that were, in part, associated with the consumption of supplements containing the drug.

Methylhexanamine is listed under many different names, including 1,3-DMAA, 1,3-Dimethylpentylamine, 4-Methyl-2-hexylamine, Dimethylamylamine, 1,3-Dimethylamylamine, 4-Methyl-2-hexanamine, Geranamine, 2-Hexanamine, 4-methyl- (9CI), Methylhexanenamine, and 2-Amino-4-methylhexane. Some companies list the drug under the name of geranium oil, geranium stems, or rose geranium in an attempt to convey its natural creation.

Benefits

Considered an unsafe food additive, the benefit claims of DMAA are unsubstantiated with no research backing them up. The stimulant properties of the drug promote its only possible benefit of it being used for increased energy, similar to that in caffeine. Other potential but unproven benefits of the drug include:

  • Boosting weight loss
  • Improving attention deficit-hyperactive disorder or ADHD
  • Increasing the effectiveness of workouts for bodybuilding
  • Boosting athletic performance
  • More research is needed to validate these benefits. The FDA does not advise consumers to purchase and products containing the drug, citing the lack of information to prove the safety of consuming methylhexanamine.

Side Effects

DMAA is thought to pose many serious safety concerns. The stimulant properties inherent in the drug pose a concern with the possibility of it increasing the chance of an irregular or rapid heartbeat, increased blood pressure, and increasing the chance of a stroke or heart attack. Consuming a stimulant such as this drug can cause increased anxiety, trouble sleeping, appetite changes, shortness of breath, chest tightness, jitteriness, and irritability. For individuals that already have issues with their cardiovascular health, it is highly recommended to avoid any kind of supplements containing the drug. Avoidance is also recommended to individuals that are pregnant or breastfeeding, have high blood pressure, or require surgery.

Clinical research indicates that the drug causes an increased heart rate and blood pressure in individuals when consumed. Several reports on the drug have been made connecting it to individuals who had consumed the drug and suffered a severe stroke, a heart attack, a toxic buildup of lactic acid in the body, or death.

Methylhexanamine interacts negatively with other stimulating drugs, including methylphenidate, pseudoephedrines, caffeine, amphetamines, diethylpropion, and phentermine.

Dosage

There is not enough scientific research on the drug to accurately provide a safe, recommended dosage of DMAA. The dosage is depended on the age, sex, health, and various other conditions of the individual wishing to take the drug. A healthcare provider should be sought for guidance on the appropriate dosage guidelines that an individual should follow.

The stimulant drug methylhexanamine is widely regarded by healthcare authorities and the FDA to be an unsafe supplement ingredient. The oral consumption of this drug can increase an individual’s heart rate and blood pressure, and in some individuals, it could lead to serious health complications. The FDA is actively working on banning all supplements that contain the drug for the health and benefit of consumers.

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08Dec

AC-262 536: Benefits & Usage

AC-262 536 is a research compound that acts as a selective androgen receptor modulator, or SARM. It is considered a non-steroid drug used in the workout and bodybuilding industry as an effective alternative to testosterone. Much like other SARMs, it influences androgen receptors in the body and helps to increase strength and muscle mass in an individual.

ac 262,536

Medical History

Developed by Acadia Pharmaceuticals, AC-262 536 was initially created to advance the treatment of prostate cancer as well as neurological disorders such as Alzheimer’s. The compound is comparable to testosterone in its ability to promote muscle growth. Unlike testosterone, the direct binding that occurs between the compound and the body’s androgen receptors allows it to promote muscle growth and strength without increasing the risk of prostate cancer, damage of sexual tissues, and heightened liver enzymes.

The compound has currently only been put through animal trials, and research is still pending at the effectiveness and benefits of this SARM. Individuals in the workout and bodybuilding industry have begun using the compound for its similarities to testosterone without the harmful drawbacks.

Benefits

While animal research has been done on the benefits of AC-262 536, no trials have been done on humans. Therefore, the benefits that this compound is said to give are unsubstantiated. Instead, most are based on the personal reviews obtained of the product by individuals electing to use it. Some of these benefits include:

  • Increased muscle growth
  • A possible decreased risk of prostate cancer by antagonizing the effects of dihydroxytestosterone
  • Possible restoration of cognitive abilities in those diagnosed with Alzheimer’s disease
  • Increased fat loss
  • Increased bone strength
  • An increased suppression of the luteinizing hormone

Side Effects

Since it hasn’t been approved by the FDA for safety and effectiveness, AC-262 536 poses some possible risks. As with most SARMs, there is an inherent risk for fatigue and nausea if the compound is taken regularly. Many individuals recommend cycling the SARM out with post-cycle therapy not only to avoid this interaction but also to prolong the strength and stamina given by the compound.

Evidence presented by various users suggests that using the SARM could cause headaches, a rise in blood pressure, changes in eyesight, and rashes developing on the skin. But these are unverified and scattered accounts. Caution should always be taken when using any unregulated supplement.

Dosage AC-262 536

It is recommended since AC-262 536 has not been approved by the FDA, that any individual wishing to try it does so under the guidance of their healthcare provider. Outside of this, following the recommended dosage guidelines is vital in preventing unwanted side effects.

The right dosage depends on an individual’s physical makeup, sex, and weight. For a general dosage, a male is recommended to take 10mg to 20mg of the supplement daily for 30 days, while a female is recommended to take 5mg to 10mg daily for 30 days. After 30 or so days, a round of post-cycle therapy is suggested. For such a SARM, 30 days of post-cycle therapy is what most users recommend. Once the post-cycle therapy is completed, another round of the SARM can begin if desired.

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As a SARM, AC-262 536 promotes muscle growth and bone strength and is typically used to bulk up muscle and cut fat in bodybuilding and during workouts. While the supplement doesn’t include much in the way of clinical research, it has been touted as a better alternative to testosterone, one with less detrimental side effects. As with any unregulated supplement, it is best to take it under the guidance of a healthcare provider.

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08Dec

Adrafinil: Usage, Side Effects and Dosage

Adrafinil is an inactive eugeroic drug used in promoting increased cognitive abilities and alertness. As it is metabolized in the body, it is converted to the active drug Modafinil. It is typically utilized by individuals with sleep disorders that affect their ability to stay awake during the day, such as narcolepsy. Unlike other wakefulness aids, such as coffee, this particular stimulant drug does not incur jitteriness or an energy crash in the individuals that use it.

adrafinil

Medical History

Adrafinil was discovered in France in 1974 by the Louis Lafon Laboratories pharmaceutical company. Given the brand name Olmifon, it was put into circulation in France in 1985 to remedy narcolepsy and other similar sleep disorders. It remained in use as a prescription drug until 2011, when the manufacturing of it was discontinued. This was done, in part, due to the discovery and apparent cost-effectiveness of manufacturing Modafinil.

The difference in the two drugs relates to the different levels of potency, how quickly it is activated in the body, and for how long. Modafinil came out on top and was thus put into circulation as a prescription drug. Once Adrafinil was discontinued as a prescription drug, it was then regulated to an over-the-counter supplement.

Benefits

Unlike many supplements, Adrafinil has had documented research done during its reign as a prescription drug to back up the beneficial claims listed for it. This benefits the potential users, as they can be confident in the supplement’s ability to help them. The benefit of this eugeroic supplement can begin being felt within 60-90 minutes of it being taken on an empty stomach and will last for about 10-15 hours. These benefits can include:

  • Raised energy levels throughout the day
  • The lack of the typical “stimulant crash” as the supplement wears off
  • A reduction in mental fatigue
  • Enhanced clarity of thoughts
  • Increased positive mood
  • An increase in both short-term and long-term memory
  • The ability to stay awake for more extended periods of time
  • Increased mental alertness throughout the day
  • Enhanced ability to focus on a task
  • Improved reaction timeIncreased motivation
  • An increase in problem-solving abilities
  • Reduced depression in the elderly caused by neurological diseases
  •  

Side Effects

Adrafinil, overall, is considered a relatively safe and non-toxic supplement. In comparison to other stimulant-style drugs, it has very few side effects. As the drug promotes wakefulness in individuals, taking the supplement too late in the day can lead to the inability or difficulty falling asleep at night. Other than the insomnia, this supplement can cause a change in appetite, nausea, and mild headaches.

Regular use of the supplement is not recommended, as extended use can increase the count of certain liver enzymes and lead to liver damage. Likewise, it is not recommended for individuals who already take any drugs that increase the enzyme count in the liver.

Dosage

While it is considered a non-toxic supplement, regular use of Adrafinil is not recommended. The dosage recommendations for the drug offers an on and off approach to taking it. Taking the required dosage every other day to every other two days a week, then going a week without it in order to keep the liver enzymes low. This will allow the eugeroic properties of the drug to stay effective and lead to fewer side effects.

The recommended dosage of the supplement is 300 mg – 600 mg every other day. Starting with the lower dosage allows the body to be used to the effects, and if the individual doesn’t feel like it’s enough, then it can be increased. The supplement must be taken immediately upon waking in the morning and on an empty stomach.

Overall, Adrafinil is a generally safe supplement for use in increasing mental alertness and cognitive functions. If taken correctly, it should cause little to no side effects in most individuals. As with all supplements, caution should be taken when trying it for the first time, and care should be given to the quality of the supplement purchased.

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08Dec

Tadalafil : Usage, Side Effects and Dosage

Tadalafil is a phosphodiesterase inhibitor used to help relax the blood vessels and increase blood flow to certain areas of the body. It is available as a generic prescription medication in the United States and the United Kingdom. This drug falls under two different brand names, the names being Cialis and Adcirca. While they are the same medication, their use and dosage are what sets them apart. Cialis is prescribed for the treatment of benign prostatic hypertrophy, which is an enlarged prostate, and erectile dysfunction. While Adcirca is prescribed to help improve the exercise capacity in men and women and treat pulmonary arterial hypertension.

tadalafil

Medical History

ICOS, a biotechnology company, created Tadalafil. The company joined up with the American pharmaceutical company Eli Lilly and Company in order to market the drug in a joint venture in 2003. Eli Lilly sold the rights to keep the drug’s formula exclusive to United Therapeutics in 2008 to commercialize the drug for use in the treatment of pulmonary arterial hypertension. Then in 2011, the FDA approved the drug to be marketed and used to treat benign prostatic hypertrophy.

The difference between the branded Cialis and other erectile dysfunction prescriptions at the time was the half-life of Cialis was double that of the others. Cialis had a half-life of 17.5 hours, while other drugs only had a half-life of about four hours. This allowed Cialis to be marketed as working for up to 36 hours.

Benefits

Tadalafil is prescribed for the treatment of an enlarged prostate, erectile dysfunction, and pulmonary arterial hypertension. It does this by relaxing the blood vessels in some regions of the body, which helps to ease the symptoms of the different ailments. This benefits those individuals afflicted with these ailments by:

  • Increases blood flow to the penis during sexual stimulation to get and keep an erection.
  • Increases blood flow to the lungs
  • Increase the level of activity an individual is able to do.
  • Decreases shortness of breath, lethargy, and dizziness associated with high blood pressure in the vessels going into the lungs.
  • Decreases urination difficulties
  • Reduces painful urination
  • Reduces the excessive need to urinate, especially at night.

Side Effects

Using Tadalafil is considered safe, overall. A doctor will need to prescribe the medication, and they will look at an individual’s medical history to gauge whether it will be a good fit for them. Caution should be taken when first being administered the drug, and any side effects should be promptly told to the prescribing doctor.Possible side effects that are common in taking this medication are headaches, back pain, congestion, dizziness, an upset stomach, muscle pain, and flushed skin. Some less common but serious side effects can include hearing loss, vision problems, and a prolonged erection that can damage the penis.

This medication is not recommended to be taken by individuals with a history of or currently have cardiovascular problems, a stroke within the last six months, liver or kidney disease, Peyronie’s disease, eye problems, or bleeding disorders. It should also not be taken with any nitrate drug or riociguat, as it can cause an unsafe drop in blood pressure.

Dosage

The recommended dosage of Tadalafil is decided by an individual’s doctor and is dependent on the reason for taking the drug. For use in treating erectile dysfunction, a 10 mg dose is typical, and the individual can elect to take it up to once a day. Either it can be taken in the morning, for all-day use, or 30 minutes before sexual activity. When used for treating an enlarged prostate, the standard prescribed dose is between 2.5 mg to 5 mg, and it should be taken once a day. For treating pulmonary hypertension, a dose of two 20 mg tablets is typically prescribed to be taken together.

Tadalafil is an FDA-approved prescription medication that is used to treat erectile dysfunction, an enlarged prostate, and pulmonary hypertension. This is done by relaxing the blood vessels of the body and increasing the blood supply to certain areas. While it does come with possible side effects, most are minor or rare, and it is generally considered a safe drug to take under the guidance of a doctor.

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08Dec

Alpha GPC: Usage, Side Effects and Dosage

Alpha GPC, or Alpha-glycerophosphocholine, is a cholinergic compound found naturally in the brain. Supplements containing this compound has been shown to promote increased cognitive function, support cellular membranes, and boost athlete’s power output. This is done by the supplement, increasing a chemical in the brain called acetylcholine. Acetylcholine is essential for learning functions of the brain and memory. The supplement also holds promise in being a beneficial ergogenic, or wakefulness supplement, but more research is needed in this area.

alpha gpc

Medical History

In the early 1990s, Alpha GPC was used in an Italian clinical trial to test its effectiveness in treating the cognitive decline experienced in individuals who had recently suffered a stroke. They treated 2,044 patients who had recently suffered a stroke with the supplement at 1,000 mg a day for 28 days and then 400 mg three times a day for the following five months. The ensuing evidence pointed to the supplement helping to improve performance on psychometric tests and improve the functionality of neuronal membranes.

Small scale studies on the effect the supplement has on physical performance have been done as well. These studies point to the possibility that the supplement increases the maximum power and velocity of an individual’s physical abilities.

Benefits

There are documented benefits of Alpha GPC, and while more research is needed to accurately prove all the benefits, the current research is promising. The potential benefits of this supplement include:

  • Improvement in cognitive skills in Alzheimer’s and other related dementias suffers after three to six months of treatment.
  • Improve the rate of recovery for individuals that have suffered a stroke if treatment is given within ten days after the stroke.
  • Enhancing memory
  • Support of cognitive function and abilities in the elderly
  • Increased cell growth, reproduction, and repair
  • Improve and support recovery from brain injuries
  • Decreased anxiety
  • Increased power output in athletic performances
  • Increase the amount of fat burned
  • Increased iron absorption

Side Effects

Alpha GPC was determined by the FDA to be mostly safe when no more than 162.2 mg is consumed daily. Possible common side effects of the supplement include headaches, dizziness, skin rash, heartburn, confusion, insomnia, fatigue, nervousness, gastrointestinal distress, and diarrhea. These side effects are more prevalent at higher dosages.
It is recommended to consult with a healthcare provider before taking the supplement, especially if an individual is prone to hypotension.
It is not recommended to be taken while pregnant or breastfeeding due to the lack of research data available.

The supplement possibly interacts with the medication Scopolamine, or Transderm Scop. Scopolamine blocks the chemical acetylcholine that the supplement increases. It is not known whether this interaction prompts a decrease in the effectiveness of Scopolamine. Still, it is recommended to speak to a healthcare provider beforehand out of an abundance of caution.

Dosage

A recommended dosage of Alpha GPC depends on the health, age, and sex of the individual taking it, and there is not enough scientific research to back up a general range of a dose. If the supplement is being taken at the suggestion of a healthcare provider, they can prescribe a recommended amount that would be right for the individual.

It is always best when trying out a new supplement to start with the lowest recommended dose, and standard dosing on the supplement’s label recommends 300 mg to 600 mg daily. If an individual is taking the supplement for increased power output during athletic performances, a 600 mg dose once a day is standard. In individuals wanting to support cognitive functions, a total daily dose of 1,200 mg divided over three smaller doses of 400 mg each is recommended.

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Overall, Alpha GPC is a generally safe supplement used to support and improve cognitive function and athletic power. With minimal side effects and adverse drug interactions, this supplement shows promise for the treatment of cognitive decline in individuals suffering from Alzheimer’s and related dementias.

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08Dec

Hydrafinil: Usage, Side Effects and Dosage

Hydrafinil, otherwise known as 9-Fluorenol, is a eugeroic drug that promotes wakefulness and increased mental alertness in an individual. It is a metabolite of Modafinil but has a shorter half-life of six to eight hours. It operates by boosting the dopamine and norepinephrine in the brain, which increases glutamate, a neurotransmitter that enhances memory and learning. The increase of dopamine also triggers an increase in cognitive abilities and alertness. In comparison to other eugeroics, this drug has a more subtle impact on energy and function, allowing for a calmer, less wired energy.

hydrafinil

Medical History

Hydrafinil was created by Cephalon Pharmaceuticals as a possible successor to the popular eugeroic drug Provigil, also known as Modafinil. Research, at the time, pointed to the drug having 39% more viability over a short span of time than Modafinil. The company eventually scrapped research into the potential of the drug, possibly due to Fluorenol being used as a bug spray in the 1930s and being found to be lethal to aquatic life.

The drug is hailed at producing more potent euphoric and eugeroic effects than Modafinil, but for a shorter time. The shorter half-life of the drug is a draw-back to many individuals, as the benefits don’t last long before they expire.

Interest in the drug spiked again in 2015 when nootropic drugs became popular. It is not FDA regulated and can be purchased over the counter either online or in select nutrition stores as a dietary supplement.

Benefits

Although Hydrafinil may be an unregulated drug, the benefits are widely noted due to it being comparable to Modafinil. Many individuals that have used the supplement report an increase in cognitive functions and clarity of thought. Other potential benefits of the supplement include:

  • Increased energy and alertness
  • Improved quality of sleep
  • An increased attention span
  • Increased capacity to learn
  • Improved memory
  • Increased motivation
  • Improvement in mood
  • A more regulated sleep cycle
  • Less addictive than Modafinil
  • Assist with overcoming addictions

Side Effects

The FDA does not regulate Hydrafinil, so caution must be taken when purchasing the supplement as different manufacturers can produce the supplement differently. In order to decrease the risk of contamination and severe side effects, a high-quality supplement from a reputable company is recommended.

Individuals that have used the drug have not reported any severe side effects, and it is generally considered to have fewer adverse reactions than that of Modafinil. The few mild side effects that have been reported include headaches, nausea, a change in appetite, dizziness, nervousness, increased anxiety, and difficulty sleeping.

As the drug has not gone through any human clinical trials, there is no accurate way of knowing the safety of its long term use. Because of this, it is not recommended for use by those that are pregnant or breastfeeding.

Dosage

As it is an unregulated drug, Hydrafinil does not have any information regarding a standard dosage. Care should be taken to not consume too much of the supplement due to its increased strength in comparison to other eugeroic drugs. A doctor’s guidance is recommended when taking such a supplement to provide more accurate dosage recommendations.

Typically, manufacturers of the supplement prescribe standard dosing of 50 mg to 150 mg daily, with no more than 150 mg a day recommended. Taking the highest dosage for multiple days in a row is also not suggested. Overall, Hydrafinil comes across as a strong eugeroic beneficial in supporting and improving the cognitive functions of the brain while also providing a stimulating boost of energy when it is needed most. At the present time, it is considered to be relatively safe to consume due to it being compatible with other scientifically backed drugs

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08Dec

Flmodafinil: Usage, Side Effects and Dosage

Flmodafinil, otherwise known as CRL-40,940, is a eugeroic comparable to Modafinil. It is claimed as a powerful nootropic that is more potent than its predecessors. When taken by mouth, the drug is absorbed quickly by the body, taking less time to kick in than other eugeroics, and it lasts 40% longer in the body. The difference between the drug and Modafinil is in the structural makeup of the compounds. This includes an additional two fluorine groups attached to the drug that is referenced in the prefix of its name. These additional groups increase eugeroic’s bioavailability. The drug is comparable to Adrafinil, Armodafinil, and Modafinil.

Medical History

Also going by the names of bisfluoromodafinil and lauflumide, Flmodafinil was patented in 2013, and clinical trials have been ongoing since 2015. Its clinical results are highly anticipated and are hoped to bring with them proof that the drug is a non-amphetamine with an increased ability to promote wakefulness and mental alertness.

This newest eugeroic targets the dopamine receptors in the brain and increases its level in the synapsis. This provides the boost in productivity, cognition, and motivation that makes eugeroic so popular. The drug also claims to have even fewer side effects and be overall a safer alternative to Modafinil.

Benefits

As it is still in its trial phase, the benefits associated with Flmodafinil are from personal accounts of individuals taking the drug. Therefore they are considered unsupported until there are clinical results to back up the claims. The potential benefits that have been documented include:

  • A boost in mental and physical energy
  • Enhanced mental focus
  • A boost in overall mood
  • Increased mental alertness
  • Boosted mental agility
  • Enhanced neurological health
  • Increased productivity and motivation
  • Increases confidence
  • Promotes a euphoric feeling of excitement in the brain to help combat depression
  • Promotes a calm demeanor
  • Reduces anger and aggressive feelings

Side Effects

Until the clinical results of Flmodafinil are released, there is no definitive way of knowing the full scope of the potential side effects and long term safety of its consumption. Personal accounts of individuals state a marked decrease in side effects in comparison to Modafinil. Those side effects that were reported typically happened when an individual took a higher dose of the drug than is recommended. The side effects that were noted include congestion, an increase in anxiety, dizziness, nausea, indigestion, diarrhea, trouble sleeping, nervousness, headaches, allergic skin reactions, irregular heart rhythms, and insomnia.

The newer eugeroic can also cause interactions with current medications and decrease their effectiveness. These medications include hormonal contraceptives, Sandimmune, Theophylline, cyclosporine, and any other prescription or supplement that affects the liver’s enzyme activity. It is also recommended to avoid alcohol while taking the drug.

Dosage

Flmodafinil is not regulated by the FDA as of yet, as it is still in ongoing clinical trials. Because of this, there is no standard dosing recommendation widely available. It is suggested to visit with a healthcare provider and take the supplement under their guidance if possible, as they will be able to provide a safer dose after combing through an individual’s medical history.

Otherwise, a dosage of 200 mg is standard on most manufacturer’s labels. Many individuals have come forward with their personal accounts of taking the drug and recommend starting at 50 mg to 75 mg a day. This is due to the potency of the product in comparison to similar eugeroic drugs.

Overall, Flmodafinil is a comparably more potent drug than its predecessor Modafinil and the benefits can be felt not long after taking a dose. While it is not FDA approved and can not be definitively classified as safe, there is little evidence to suggest otherwise. Information gathered from personal accounts show a lack of adverse reactions or severe side effects.

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08Dec

Bromantane: Usage, Side Effects and Dosage

Bromantane, also known as Ladasten, is a stimulant nootropic drug that helps the brain increase and regulate its dopamine and serotonin neurotransmitters. This increase and regulation help to enhance mental and physical performances of the body. The drug is derived from adamantane, and it has properties that are similar to amphetamine-like stimulants. Due to the unique aspects of the drug, it is sometimes classified as an adaptogen and actoprotector, which are drugs that enhance physical and mental resistance to extreme environmental conditions and stress.

bromantane

Medical History

Bromantane was developed in the Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences in Moscow, Russia, in the 1980s. It was initially used to improve the work performance of individuals in high stress or extreme environments. Consumption of the drug prompted better focus and motivation on job sites.

Notably, the drug was given to the Soviet and Russian militaries to lessen the recovery time for soldiers after any intense physical exertion. It was approved for widescale distribution around Russia in 2009 for the treatment of Neurasthenia. The FDA in the United States has not entirely approved of the drug as of this time. Ongoing clinical trials are looking into the best dosage of the drug and for repeated scientific proof of its benefits.

The actoprotector effects of the drug can be felt within one to three days from the first dose, while the stimulant effects can be felt within one to two hours. These stimulant-like effects can last for up to eight to twelve hours.

Benefits

Bromantane touts many stimulating and nootropic-like benefits from its consumption. While the drug has regularly been used as an adaptogen in Russia, its benefits have not been proven with enough scientific evidence to merit approval by the FDA. As such, the promised benefits are not guaranteed. The potential benefits of the drug include:

  • Reduced symptoms of Neurasthenia
  • Improved quality of sleep
  • Improved productivity
  • Improved motor function
  • Reduced anxiety and nervousness
  • Increased mental alertness
  • Increased wakefulness during the day
  • Improved short term memory
  • Increased motivation
  • An improved attention span
  • Reduced inflammation
  • A more stimulated immune system during stressful situations
  • An enhanced feeling of calm
  • An improved mood

Side Effects

The lack of scientific evidence on Bromantane makes it difficult to surmise the effect it will have on individuals. Most of the current information on the drug’s side effects comes from personal stories from individuals who regularly use the drug and a few animal trials.

For the most part, the noted side effects seem to be mild, with more severe reactions related to the consumption of a higher dosage. The potential side effects of taking the drug include increased urination, vomiting, diarrhea, depression, brain fog, fatigue, confusion, insomnia, and a crash in energy.

Dosage

Bromantane does not have an official dosage recommendation due to it not being FDA approved, and there’s been no extensive testing done to find out the proper dose. Because of this, it is highly advised to consume the drug under the guidance of a healthcare provider. A healthcare provider can help figure out the right dosage for the individual and monitor for any adverse reactions or side effects of the drug.

The standard dosing given by manufacturers is from 50 mg to 100 mg a day. Although it has been noted that women metabolize the drug faster, and therefore will require a higher dosage than that of men. Athletes also prefer to take a higher dosage in order to optimize their performance. It is best to start with the lowest dose to see how the body reacts to it and go from there. It is not recommended to take more than 1000 mg a day, as the body will develop a tolerance for it, and the benefits will plateau.

Overall, Bromantane is a stimulating nootropic drug used to improve the body’s and mind’s performance during stressful or extreme conditions. While there is a lack of credible scientific evidence for the drug, it holds little in the way of side effects and is generally considered safe to consume.

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08Dec

Capromorelin Tartrate : Usage, Side Effects and Dosage

Capromorelin Tartrate is an investigational drug that stimulates the secretion of the human growth hormone. It mirrors how the human body usually produces the human growth hormone during puberty and into young adulthood. While the drug was initially being researched for the treatment of muscle weakness and fragility in elderly adults, the results were not substantial enough to continue the clinical studies. The drug is currently being studied for use in treating underweight dogs.

Medical History

The most notable human trail for Capromorelin Tartrate began in 1999 and ran for a year. During that year, scientists had 395 people between the ages of 65 and 84 who take the drug daily. After six months, the participants saw an average increase of 3 lbs of lean muscle mass gained as well as increased balance, strength, and coordination. After 12 months, the participants saw an overall improvement in their ability to climb stairs. While these results were good, they were not good enough to continue into the second year of the trial. Similar human trials continued up until 2017.

In 2017 a set of animal trials began to test the viability of the drug on dogs. These tests measured the appetite stimulation that occurred in the animals after consuming the drug. The weight that was gained was also measured in the trial. The success of these trials led to the FDA approval of the drug for prescription use on dogs. The medication brand was named Entyce®, and it is still available from a veterinarian.

Benefits

While the benefits of Capromorelin Tartrate has been widely researched for animals, there is still inconclusive evidence for human consumption. The documented human trial noted that the drug could possibly be used to treat the functional decline of older adults, but the trials were not completed due to a lack of results. The potential benefits of the drug can include:

  • An increase in the body’s lean muscle mass
  • Increased physical strength
  • Improved balance
  • Enhanced coordination
  • An increase in appetite
  • Reduced physical weakness due to age or illness
  • Improvement of body composition and physical function

Side Effects

During the human trials of Capromorelin Tartrate, several mild to moderate side effects were noted. But since the trials were stopped, there is no substantial evidence of the long-term health and safety of taking the drug. The possible side effects of taking this drug include a drop in blood pressure, insomnia, excessive fatigue, insulin resistance, an increase in fasting glucose, nausea, and bloating.

There is not enough scientific information to know whether or not the drug is safe to take for women who are pregnant or breastfeeding, and it is not recommended. It is also not recommended to take the drug if an individual is on any prescription medication until they speak with their healthcare provider, as there is a possibility of unknown drug interactions.

Dosage

An accurate dosage of Capromorelin Tartrate has only been discovered for use in dogs. Therefore, it is suggested that an individual wishing to take the drug do so under the guidance of their healthcare provider. The scientific evidence from the human trial of the drug notes that a dosage of 6 mg to 20 mg was given daily as well as a dose of 10 mg three times a week. While this range of dose varies, it is recommended to begin a dosage at the lowest possible amount for safety.

The drug is available as a supplement online in both powdered and liquid form. There are also separate listings for the drug for use in cats and dogs to increase their appetite.

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Overall, Capromorelin Tartrate has had some success in human trials in treating the physical weakness that accompanies old age. Still, the trials were halted before a proper amount of information could be collected. Due to this, the FDA has only approved the drug for use in animals, and it is not recommended for human consumption.

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08Dec

Cyclazodone: Usage, Side Effects and Dosage

Cyclazodone is a stimulant drug that is used to help enhance the mental focus of an individual and has found recent attention as a study aid. It is a derivative of pemoline but exhibits more potent stimulating and nootropic properties than it. The patents for the drug detail that it reduced fatigue with less stimulatory activity and less toxicity than that of amphetamines. While the drug has the possibility of being a potent nootropic and stimulant, the FDA has not approved it to be used as such due to the lack of scientific information and clinical trials.

cyclazodone

Medical History

Cyclazodone was formulated in the 1960s by the American Cyanamid Company but was not widely known before it appeared online in the research chemical market in 2017. The effects of the drug are similar to those produced by amphetamines, and there is concern about it becoming an addictive substance due to its being used recreationally. Caution should be taken when consuming the drug, as there is an overall lack of pharmacological information and limited clinical data available for the drug. Therefore there is no sure way of knowing how toxic the drug can be or how severe the reactions may be from long-term usage.

Benefits

The benefits of Cyclazodone are unsubstantiated in the scientific community and can not be accurately surmised because of this. Any potential benefits noted are from scientific theories on how the drug may work or personal anecdotes from current users of the drug. The possible benefits of the drug include:

  • Provides cognitive and physical stimulation
  • Increases mental alertness and focus
  • Increases energy
  • Decreases drowsiness
  • Positive improvement on an individual’s mood
  • Increased sociability
  • Promotes a euphoric feeling
  • An increased relief from pain
  • A reduction of symptoms of anxiety
  • Increased confidence and self-esteem
  • Increased libido
  • Enhanced clarity of thought

Side Effects

There have been no human studies to prove Cyclazodone’s safety, and it is recommended to use harm reduction practices if an individual chooses to consume the drug. A wide range of reactions have been noted by personal usage, but very little scientific evidence is available. It is generally understood that most adverse reactions happen when an individual takes a higher dosage, while lower dosing seems to be relatively safe. The potential side effects of the drug include frequent urination, increased body temperature, temporary erectile dysfunction, dry mouth, compulsive redosing, increased heart rate, teeth grinding, muscle cramps, a change in appetite, nausea, increased anxiety, headache, and irritability.

Unlike some drugs, there are also after-effects that are associated with taking this drug. These after-effects can include cognitive fatigue, headaches, a lack of motivation, muscle cramps, delusions, anxiety, depression, psychosis, depersonalization, insomnia, tactile hallucinations, and slowed down thoughts.

It is not advised to combine the drug with other substances, as it can cause moderate to severe reactions in some cases. It should not be taken with alcohol, MDMA, cocaine, Tramadol, and any other stimulant drug.

Dosage

Cyclazodone is not approved by the FDA and does not have standard safe dosing guidelines. It is recommended to take the drug under the guidance of a healthcare provider for the safest experience. Individuals who wish to try the drug are also advised to take the lowest recommended dose in order to gauge their body’s reaction to the drug.

The dosage guidelines for research purposes denote a low dose as 5 mg and should be taken irregularly to prevent a tolerance build-up. A moderate dose is between 5 mg to 15 mg and should also be taken irregularly. Finally, a strong dose is listed at 25 mg to 30 mg, and no more than that should be taken at once. The drug is sold in pill and powder form from a 1 mg dosage to a 30 mg dose.

Overall, Cyclazodone is a potential beneficial stimulant and nootropic. More scientific research is needed to determine its benefits and safety. While the drug can be taken for research purposes and to treat those with ADHA, caution is recommended due to the current lack of information on its side effects and toxicity.

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