08Dec

S23: Dosage, Usage and Benefits

As mentioned previously, S23 is a type of Selective Androgen Receptor Modulators or SARM. Pharmaceutical company GTx Incorporated operating out of Tennessee in the United States initially developed S23 by modifying an existing SARM known as C6, making it much more useful than its predecessor.

Here’s the best part: they initially developed S23 as a potential male hormonal contraceptive. You read that right! At first, S23 aimed to act as a form of birth control!

However, the people behind S23 discovered that it had excellent anabolic and androgenic benefits as well. Most importantly, those benefits came at a good ratio to each other, proving to be useful beyond just a potential form of male birth control.

Many users around the world have discovered first-hand that S23 is a powerful anabolic chemical that provides them with massive gains.

What are the benefits

The S23 SARM comes with a long list of excellent benefits. While most people focus mainly on the ones that relate to their fitness goals, the fact is that this SARM also offers benefits that may go beyond a person’s fitness goals.

Here are some fitness-related benefits that the S23 SARM offers:

  • Increased muscle mass The biggest attraction to the S23 SARM comes from this benefit. Using it helps you to increase your muscle mass at a much faster rate than usual. Some users claim to have gained upwards of 10 pounds of lean muscle mass from a single cycle of using the S23.
  • More efficient fat loss While the S23 SARM promotes increased muscle mass, it simultaneously makes the fat loss process much more efficient. Combining both benefits offers a chance to get ripped much more effectively.
  • Faster post-workout recovery The best supporting benefit that S23 offers is quicker recovery between training sessions.

And here are some other benefits of using S23 that might not relate to your fitness goals directly:

  • Potential male birth control While this benefit is still under research, the product does show great potential in acting as a form of male birth control. To be exact, its potential is in working as a hormonal form of birth control that relies on the male endocrine system to function.
  • Higher bone mineral density Using the S23 also leads to higher bone mineral density. As a result, bones become much stronger, which may support your health and fitness goals indirectly.
  • A lack of “night vision” side effects The S23 does NOT involve the adverse side effects that cause problems with your vision, particularly at night, unlike some other SARMs on the market.

Side effects

The SARM is generally safe, and plenty of satisfied users are living proof of that. Still, to make a well-informed decision, there are a few things you need to know about it. These include:

  • Increased acne and hair loss Unfortunately, users have reported an increase in acne on their faces and backs as a result of cycling S23. On top of that, some have also experienced increased hair loss which they point to the the product as its cause.
  • Unexpected aggression Some users have also shared that they’ve felt an increased sense of aggression, which is something to be cautious about when using S23.
  • Suppression of testosterone Testosterone levels are also at risk of dropping. One step that some users have taken is to monitor their T levels more actively when on S23.

Generally speaking, here are some facts to keep in mind about the S23 in its current form:

  • Its long-term effects are still unknown The fact of the matter is that nobody knows what the long-term side effects of it might be. While there are plenty of promising studies supporting the benefits, most of what we know is anecdotal from people who have used it before. Remember: not everybody responds the same way physically to things like SARMs.
  • It is still not approved by the FDA The Food and Drug Administration (FDA) has not approved the S23 SARM. That might change in the future, but the fact is that it does not have that approval at this point in time.
  • It requires more clinical studies The bottom line is that the SARM requires more clinical studies, especially human studies. Animal studies are promising, but for there to be absolute certainty on the positive and negative effects of SARM, its developers need to perform more human clinical studies on it.

Dosage and Cycles

If you’ve decided to use the S23 , here’s one more thing you need to know: the lack of human clinical studies means that no one has discovered the ‘ideal’ dosage for humans yet. Based on what we know from past users, taking 10-25 mg of the S23 SARM is what most users consider to be the best practice for now.

To be precise, newbies are best off starting with 10 mg per day, before graduating to 15 mg/day for intermediates, and eventually 25 mg for more advanced users.

It’s best not to exceed that daily amount, or to do so at your own risk.

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08Dec

SR9009: Dosage, Usage and Benefits

What is SR9009

SR9009, more popularly known as Stenabolic, originated from the lab of Scripps Research Institute’s own Professor Thomas Burris. Although it’s affiliated with SARMS, SR9009 is rather a Rev-ErbA agonist drug.

Did I already confuse you? Basically, the protein Rev-ErbA is found in the brain, liver, skeletal muscle, and body fat and it plays a role in one’s circadian rhythm.

Now for the kicker! The Stenabolic compound affects this protein so much that mice test subjects ran at a 50% increase in speed after taking SR9009. It also radically reduced obesity in mice. The mice were injected with SR9009 for a week. Although they lost fat, their food consumption remained the same. After 12 days, the mice stopped putting on weight without any differences in insulin tolerance or glucose count. After 7-10 days, the tested mice’s cholesterol reduced significantly, and after 30 days they demonstrated escalated endurance.

Due to Stenabolics immense effects, some have coined it as ‘exercise in a bottle.’ This compound stimulates greater production of mitochondria, therefore enhancing metabolism and muscles.

So, if you want to break your fitness records or find yourself needing to outrun a werewolf, this may be just what you’re looking for. Before you make any decisions, let’s evaluate this drug further…

Benefits

Sorry if I got carried away with the mice. Let’s talk about how this might affect you and your fitness goals.

Killer Endurance 

The mice have spoken, and they can vouch for SR9009 in that it will amp up your game.

First, let’s talk about cardio for a second. Cardio is typically performed to increase one’s heart rate to where one’s capacity is maximized. If you struggle with cardio, your heart rate skyrockets. When you use stimulants like pre-workout, that skyrocket happens way faster, so it’s actually hurting your workout.

Stenabolic is your knight in shining armor. Opposite to what a stimulant does, SR9009 prevents you from getting winded so easily and enables you to go even harder. Your heart rate might just rise to 75% rather than 90% when running at the same speed.

Safe Fat Loss for Your Next Competition 

Stenabolic will reduce your body fat regardless of your current build. Typical fat burners tax your body. Thankfully, Stenabolic is not considered a stimulant or harsh drug, and keeps you burning fat even when not exercising. Hop in the gym and that fat loss will be shockingly amplified.

As mentioned a few moments ago, Rev-ErbA regulates fatty acid liver metabolism. Stenabolic enhances this process, further increasing the metabolism. Also, because SR9009 increases mitochondria strength, stored fat burns away.

Your Cholesterol Will Thank You

You don’t have to be an athlete or avid gym goer to reap the consequences of Stenabolic. If you’re obese, this drug does the honor of improving your cholesterol and exiling overabundant glucose.

Consequently, you’ll burn fat much quicker before and after your workout and get a more beneficial exercise session.

Benefits

  • It’s effective in treating sarcopenia, which causes a loss of muscle strength as you age.
  • It decreases inflammation: mice showed a decrease in lung inflammation resulting from decreased production of TNF-alpha.
  • It decreases anxious behavior.
  • It decreases tissue damage (fibrosis).
  • Because it affects our sleep/waking patterns, it can be helpful for night shift workers or constant travelers who need more control over their sleeping patterns.

Side Effects

You read that right. There are no known side effects of taking SR9009 if you follow the recommended dosage. The drug is non-estrogenic and non-androgenic, so it is great for any gender and body type. Although Stenabolic does not damage your liver, some users suggest taking liver supplements while on it.

Of course, if you happen to notice anything unusual, you should immediately stop taking Stenabolic.

Dosage

Using Stenabolic is very simple as long as you are good at time management. There’s no established human dosage for people, but professional bodybuilders have stepped in to assist.

Generally, they recommend 20-30mgs every day, but some users suggest a wider range of 10mg-40mg. Let’s not forget, the dose you take depends on what your fitness and health goals are as well as your body’s response to the drug. Remember to listen to your body!

Our bodybuilder friends also advocate for doing an 8 week cycle on Stenabolic followed by 8 weeks without it to prevent a tolerance build up.

Here’s where your time-management skills come in: SR9009’s half life is quite short. You should take it about 2-3 times a day and evenly spread it out during your waking hours. For example, if your goal is to take 40mg per day, try taking 10mg 4 hours apart to get the maximized result. It’s best taken with food, so you can even pair it up with every meal  so you don’t forget when to take it.

Stacking SR9009 With SARMS 

If you are on a SARMS cycle or planning one soon, Stenabolic can elevate your experience by being used in a stack.

On a cutting cycle? Pair Stenobalic (5-20mgs per day) with Primobolan (400mgs per week) plus a small testosterone dose. Some users prefer to pair SR9009 with Cardarine because Cardarine gives a steady stream of fat oxidation during the day while Stenabolic helps fat oxidation while exercising.

If you’re on a recomp mission, some suggest pairing Stenabolic (5-20mgs per day) with Ostarine Ostabolic (25mgs per day) and Testolone (10mgs per day).

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08Dec

SR9011: Usage, Dosage & Benefits

What is SR9011?

SR9011 is a Rev-ErbA agonist and is counted as one of the next big super drugs that might reign the pharmaceutical industry for a long time. SR9011 and the other agonists in the same series have maintained their research and observation status since 2012.

Nearly eight years ago, the National Institute of Health issued grants and established funds for the project. Pharmacy research Professor Thomas Burris developed the research drug at St. Louis College of Pharmacy.

The compound is still going through its intermediate stages of the trial. As of October 2020, the SR9011 is still not declared publicly available for human consumption. The lab and clinical trials have yet a lot to reveal.

sr9011

Benefits

To fully understand the beneficial effects of agonist SR9011, it’s necessary to understand what the compound actually does. SR9011 is a Rev-ErbA agonist, which means it binds itself to the Rev-ErbA protein in our body and enhances its working functionality. 

Rev-ErbA protein that naturally exists in our system is a major structural component. It is found in the liver, muscle tissues, fat tissues, and the entire skeleton. Needless to say, an imbalance or deficiency of the compound can lead to a host of problems ranging from depression to physical weakness. The introduction of SR9011, under controlled clinical trials, has shown the following benefits:

1.     Enhanced Endurance According to the research done so far, SR9011 is capable of increasing physical endurance. As we mentioned earlier, there’s an ample requirement of the Rev-ErbA protein compound in our system to sustain energy for physical endurance.

With this in mind, the SR9011 is expected to boost endurance or meet the minimum requirements for a healthy and fit body. Bodybuilders and those who want an athletic figure can definitely benefit from this.

2.     Lower Body Fat As it is widely known, body fat has a more disadvantageous influence on our body than any positive effects. It is responsible for making physical fitness tougher than usual. Body fat also contributes to a series of body disorders.

Exercising and dieting are the two most common ideas that people have in mind for lowering their composition of body fat. The main aim is to boost our metabolism so that the diet we consume is effectively used instead of deposited as body fat.

The SR9011 helps with a faster metabolism that helps to get rid of all the extra pounds on your body. This is why the SR9011 is also often dubbed as the ‘exercise in a pill.’

3.     Works Against Inflammation Inflammation from dietary, medical, or any other condition takes time to settle down. Heartburn and an acidic feeling can also negatively impact your health and make it impossible to recover from poor heart and liver conditions.

The SR9011 agonist that binds itself to Rev-ErbA protein is quite effective in countering inflammation. It influences and inhibits the growth of inflammatory cells.

4.     Reduces Recovery Times Since SR9011 helps speed up metabolism and lower inflammation, it is also capable of speeding up your recovery rate. You won’t feel lazy or dull anymore. Combining this idea with the fact that SR9011 is a potential fat remover, you can rely on the drug to boost your gym performance as well. Not only this, but this super drug can also easily relieve the body of soreness and strains that result in surgical or operative procedures.

5.     Increase Concentration and Focus Another evident advantage of taking the drug is that it boosts your activeness, not in just the physical sense but also in your mental capacity. The drug is a reliable companion when you’re trying to evade sleep and focus on catching up with deadlines. Even with tough jobs that seem to bore you to death, the drug may do a good job of helping you to focus.

6.     Helps With LDL Cholesterol Levels SR9011 is also useful for those who can’t control their diet and exercise routine. The drug has been found to lower LDL levels in the body without any other assistance.

7.     Acts as an Anxiolytic Lastly, you’ll be glad to know that SR9011 is also effective in calming your nerves and giving you the peace of mind you need in particularly anxious situations. If you are diagnosed with clinical anxiety, you may definitely look into treatment options that include SR9011.

Side Effects of SR9011

Right now, this next possible super drug may sound like something straight out of our dreams. However, the lab tests and clinical trials are still not complete and may reveal the possible side effects that the drug may bring. As of now, there’s only one side effect that you may need to fear:

Symptoms of Insomnia

SR9011 is known to boost concentration and focusing abilities. Consequently, the drug also contributes to wakefulness, which sometimes may seem similar to symptoms of insomnia.

Apart from this, there’s another sensible reason to keep your distance from the drug: it still hasn’t been officially declared safe or legal on a large scale. Trials are still underway, and we may expect some modifications in the compound structure before it’s accessible to the public.

Dosage

Just like any other drug, it’s best to start with a prescription. Consult your healthcare provider if you feel like you need to try out the drug for medical purposes. Remember, SR9011 isn’t meant to be a recreational drug. Its use is strictly confined to medical effects, so consuming the drug with any other purpose may do more damage than any good at all.

When you’re starting, it’s best to go with a small dosage. Anywhere between 10-30 mg a day is ideal for observing limited beneficial effects without any side effects. This is a general dosage recommendation. If you’re going for a particular brand that sells SR9011, you can try out the prescribed dosage that’s given on the package.

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08Dec

YK11: Dosage, Usage and Benefits

YK-11 is a synthetic steroidal selective androgen receptor modulator (SARM).  SARMs are very similar to steroids because they increase muscle growth and can help with fat loss, but they were designed in the hopes of having less severe side effects than steroids while also preventing the possibility of addiction.

While there are many SARMs out there in the market, YK-11 is fairly new.  That said, it is a formula that was developed by a Japanese research firm and abandoned before any tests were conducted on animals or people.

Despite this, there are several YK-11 products on the market that can be purchased.  These products, like all other SARMs, have not been approved by the Food and Drug Administration (FDA).  There is no guarantee that these YK-11 products contain what the companies claim that they do.

There is no quality control or regulation for YK-11 supplements, so you will never know if what you are taking is actually YK11 or if it is just a combination of other SARMs masquerading as YK-11.

Another important thing to know about YK-11 is that it is forbidden by organizations such as the FDA and by the World Anti-Doping Agency (WADA).  Therefore it is not recommended to use this in any kind of competition, as that can disqualify you.

Does YK-11 have any beneficial effects?

Well there are a few obvious benefits to taking a daily supplement designed to help build muscle.  First and foremost, YK-11 helps you grow more muscle in a smaller amount of time.  YK-11 is a myostatin inhibitor which makes it easier for your body to develop more muscle.

In addition to more bulk, your muscles will become stronger from the production of follistatin.  So as you can imagine, the stronger your muscles are the more you can do with them.  Like steroids, YK-11 and other SARMs promote bone health and can make your bones stronger.

As mentioned earlier, YK-11 also helps with fat loss by replacing that fat with muscle.  There are also claims that YK-11 helps boost libido and that it allows you to work out harder and longer.  YK-11 can also help you retain the muscle that you have built.

What about side effects?

Most supplements or medicines on the market have some sort of side effect.  YK-11 is no exception to that fact, and as a SARM it has quite a few potentially harmful side effects.  The biggest side effect is that it is very bad for both your liver and kidneys.

Other reported side effects include lower testosterone (which also means lower libido), impairment of cognitive function, hair loss, joint pain, and prostate issues.  The full extent of side effects, including long term, is not known as there is little to no clinical data for YK-11.

There is also evidence that suggests potential impairment to the function of other organs in your body.  It is important to keep in mind that all reported side effects come from bodybuilders who have used YK-11 and has not come from any clinical trials or data.

What is the recommended dosage and how is it used?

The recommended dosage of YK-11 is around 10-15 mg daily.  It is often recommended that you take 5 mg in the morning and then another 5mg at night.  Some bodybuilders will stack YK-11 with other SARMs like Andarine or RAD140.

You may need to adjust the dosage as needed to find one that works best for you.  If you have never used any SARMs before you may want to consider just using 5 mg per day to start.  However, if you have more experience with SARMs you can certainly go with higher dosages than 10-15 mg.

The one thing you will need to keep in mind is that the higher the dosage the worse the side effects will be.  You will need to keep this in mind since YK-11 and other SARMs can have very unpleasant side effects.

As far as using YK-11 goes, there are several methods.  The first is oral via a tincture or tablets.  The second one involves injecting the substance directly into your muscles.  No matter how you take YK-11, the important thing to remember is which cycle you will want to use.

The first cycle is to take YK-11 consecutively for six weeks.  The more advanced cycle is taking it consecutively for eight weeks at a higher dosage.

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08Dec

GW0742: Side effects, dosage and Usage

What is GW0742

GW0742 is a recently famed drug, often mentioned in comparison with Cardarine. This drug is mostly used by athletes to improve their stamina. The fat affecting properties of GW0742 also make it a good promoter of energy in the body. Additionally, this drug helps increase the oxidative abilities of your body muscles.

A PPARδ/β agonist, GW0742, has been investigated for its usage as a drug by GlaxoSmithKline. Its atomic structure reveals just one minor difference between GW0742 and Cardarine. Yet, this drug takes the lead over Cardarine. Many people claim that GW0742 is around 200 times more effective than Cardarine.

The uses and mode of action for GW0742 are almost similar to those of Cardarine. However, this drug is more powerful and has many additional benefits too. Several studies to discover other possible uses of GW0742 are currently underway. It is expected that more information about this drug will be revealed soon.

Mode of Action of GW0742

Even when many believe so, the GW0742 is not a SARM. Rather, it is one of the PPAR delta agonists and hence works just like any other drug of its group.Among many other things, GW0742’s most obvious job is to break down the fats inside your body. Such a break down provides your body with intense energy.

It is because of this energy production that the athletes are expected to use GW0742 the most. Even very small doses of this drug are supposed to significantly help produce energy, increase endurance, and enhance one’s stamina.

GW0742 has also been reported to have great effects on insulin sensitivity. This drug’s intake increases the body’s sensitivity towards insulin, hence reducing the risks of Type-II diabetes occurrence.

A few trials of this drug have also proved it to be a great protective drug for the human heart. GW0742 has been proved to help with right heart hypertrophy by altering the causal gene’s structure in the rats. Other than these few, many other studies of this drug and its effects on lab rats are being tested for credibility. Once approved, we are soon expected to have a lot more useful information about this drug and its benefits.

Benefits of GW0742

As already stated, most of the studies on the effects of this drug have not been validated yet. However, there are a few proven and widely accepted benefits of GW0742 that almost no one resists from talking about openly. Some of these are as follows:

1. Lowers the body’s cholesterol levels

A not-so-recent study performed on rats to investigate the effects of GW0742 revealed it as a great drug for maintaining the body’s cholesterol levels. The drug, once it reaches inside the body to the target points, reverses the process of cholesterol transport to blood.

This way, most of the cholesterol taken by the body is forced towards the digestive tracts and later gets excreted from the body. The reduction in the body’s cholesterol levels (when it is high) often saves the body from many severe health issues, including heart problems and diabetes.

2. Handles body lipids better

Lipids, especially tri-glycerides, need to be maintained on strict levels inside the body. Any failure to maintain the lipid profile can cause severe damage to your heart. Increased lipid concentration in the body can often prove fatal. This concentration is very difficult to be brought down once the lipids have accumulated inside.

GW0742’s intake has been proved to improve the body’s lipid metabolism when taken in very small doses. Such a property makes GW0742 a determiner of the body’s great lipid profiles. It may also label it as a lifesaver someday.

3. Cures inflammation in the Gut region

Gut inflammation is one of the worst possible swelling issues the human body has to go through. Most of the time, people get to know their gut’s inflammation only when the condition has worsened. This leads the patient to go through a lot of pain and may also prove fatal sometimes.

Thankfully, some amounts of GW0742, if taken regularly, can help with gut inflammation by decreasing the swelling. Using this drug can also reduce the painful sensations that arise from an inflamed gut, thus bringing the patient a lot of relief.

These benefits of GW0742 presented up till now are the ones you cannot expect from Cardarine. Other than these, this drug also comes with almost all the benefits of Cardarine. Given below is a summary of its other such benefits:

  • Better workout results: GW0742 is a great drug when it comes to increasing fat degeneration inside the body. This makes it very beneficial for anyone trying to get rid of their body fat throughout the exercise and other physical activities.
  • More energy: The break-down of the stored body fats by GW0742 results in more energy production in the body. This is especially helpful for anyone with a high physical activity rate. More energy production helps people feel less tired and keeps their stamina active for longer.
  • Improved heart health: GW0742’s regular intake helps your heart and circulatory system in several ways. It strengthens the valves, helps improve the rate of blood flow, keeps the arteries clear of any clogging, and makes the cardiovascular muscles stronger.
  • Lesser inflammation: GW0742 is very effective in avoiding body inflammation and in keeping the veins and vessels healthy.
  • Better kidney and liver: A faster breakdown of fats and the maintenance of body lipids help GW0742 in keeping the kidneys and liver healthier and working normally for a long.  Lesser fats in the body and reduced chances of inflammation as a result of GW0742 intake diminish the chances of disease development in any of these organs.
  • Reduced chance of skeletal system problems:GW0742 avoids the inflammation and fibrillation in bones and cartilage. This makes it a good agent to keep the skeleton healthier for a long, reducing any chance of related diseases.

Side Effects Of GW0742

The best thing about this drug’s intake is that it comes with no fatal or major side-effects as such. All you have to do is take care of the dosage and don’t take GW0742 every day unless asked by a medical practitioner. Ensuring this, you’d probably contract no such side-effect of GW0742.

The only risk associated with this drug’s intake in some people is developing a bigger than the normal heart. If you doze on considerable grams of GW0742 every day, your body might have alleviated levels of activated calcineurin.

The activation of this element causes the heart to expand, sometimes becoming a hazard for life. However, it’s not clear whether or not this side-effect of GW0742 is experienced by everyone. Chances are, only some already ill patients may develop a bigger heart after consuming this drug. If this is proved true, then GW0742 can become the world’s next wonder drug because it has no other side-effect for healthy people at all.

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08Dec

Resveratrol : Dosage, Usage and Benefits

You’ve probably already heard people say red wine is good for your health and especially heart health. This is true, as numerous clinical trials have confirmed it. But, do you know what it is that makes red wine so beneficial? Well, the compound responsible for the health benefits of red wine is Resveratrol.

resveratol

What is Resveratrol?

Resveratrol is a natural polyphenol compound found in some berries, peanuts, red and purple grapes, and dark chocolate. The compound is found in high concentrations in the seeds and skins of berries and grapes. These are also the parts of the grapes that are mostly used in making red wine, and that’s why Resveratrol is also present in high concentration in red wines.

Resveratrol also has powerful antioxidant properties that protect cells against oxidative stress.

While Resveratrol can be consumed from natural food sources, many people prefer using supplements because they deliver more of the compound. This explains why resveratrol supplements are becoming quite popular.

Resveratrol supplements are manufactured using skins and extracts of red grape and red wine. Some supplements extract Resveratrol from an Asian plant known as Polygonum Cuspidatum.

The supplements promise many different benefits, some of which are not even supported by any scientific evidence.

Health Benefits of Resveratrol

Most of the research on Resveratrol involves animals and test tube tests. There have been very few trials on humans, so it’s challenging to fully comprehend the short and long-term effects of this polyphenol compound.

With that said, here are a few of the benefits that have been identified by the studies:

  1. Improved Heart Health

Resveratrol may boost your cardiovascular health in various ways. Perhaps the most proven way is through lowering blood pressure by reducing systolic blood pressure (the number that appears at the top of blood pressure readings). Systolic blood pressure is common among old people as it is caused by stiffening arteries. Studies show Resveratrol can increase nitric oxide levels to dilate the blood vessels and improve blood flow.

Resveratrol can also boost heart health by increasing good HDL cholesterol and fighting the formation of blood clots.

It’s worth noting that the studies supporting these benefits used high doses of Resveratrol. The scientists also recommended further human trials on the same.

  1. Improved Aging and Longevity

Some reports claim that Resveratrol can extend the lifespan of certain organisms. Several animal trials have been done to investigate this effect. These produced rather mixed results. Some organisms did experience prolonged lifespan by as much as 60%. However, this was observed in organisms that are less related to humans, so it’s highly unlikely that humans will experience the same effect.

More clinical trials are necessary to determine whether there is a direct link between Resveratrol and lifespan.

  1. Slows Down Cancer Cells

Several animal and vitro studies suggest that Resveratrol can fight cancerous cells. The studies show that this compound can prevent the growth of cancer cells, and it can change the expression of certain genes to prevent the spread of cancer. Some reports also claim that Resveratrol can change the expression of certain hormones, and in doing so, it can combat some hormone-dependent cancers. In general, the studies claim that Resveratrol can fight cancers linked to the breasts, colon, prostate, and skin.

Sadly, the research on this subject is limited to animal and lab tests only. It’s hard to tell whether Resveratrol can have a similar effect on humans, how it can do so, and at what dosages.

  1. Protects the Brain

Resveratrol has antioxidant properties that can protect the brain and fight age-related cognitive decline. The compound can also fight inflammation, another common cause of brain cell damage that affects cognition.

Research shows that Resveratrol can inhibit the activities of a protein called beta-amyloid, which plays a role in the formation of plaques that are linked to Alzheimer’s disease.

Additional research on the link between Resveratrol and neurodegenerative disorders like Alzheimer’s should be very interesting.

  1. Improves Insulin Sensitivity

Resveratrol can increase insulin sensitivity and reduce the risk of developing diabetes. It can also prevent diabetes complications by activating AMPK, reducing inflammation, and inhibiting sorbitol. Sorbitol is a sugar alcohol that induces oxidative stress.

The effects of Resveratrol on insulin sensitivity and diabetes as a whole have been observed in animal studies only. The scientists also reported that Resveratrol is likely to be more effective on people who already have diabetes than those who don’t.

Resveratrol Side Effects

One of the many downsides about a compound that is not thoroughly studied is you can’t tell what to expect. The possible long-term side effects of taking Resveratrol remain a mystery. The good news is that animal studies have not indicated any severe side effects. Hopefully, that would be the same case in humans.

Drug interaction is a serious concern here as well, so don’t use resveratrol supplements without a doctor’s approval if you are under a different medication. Studies show that it can interact with blood thinners like ibuprofen and aspirin.

Resveratrol Dosage

Another problem with Resveratrol is there is no reliable guideline on dosing. Studies show that you need to take it in high doses to achieve some of its benefits. In some trials, scientists used between 250 and 1000mg of Resveratrol. It’s really hard to know what exact dose you need to take. Consider talking to your physician before using Resveratrol.

Where to buy Resveratrol

Resveratrol joins the long list of highly promising compounds that can be very beneficial to humans. The major challenge is the lack of enough clinical trials to give us answers on the exact benefits it can produce

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08Dec

Omberacetam (Noopept) : Dosage, Usage and Benefits

Nootropics or “Smart Drugs” are substances used for enhancing cognitive functions. They stimulate different parts of the brain to improve your memory, learning ability, decision-making, and mood. Some of them are also used as neuroprotective drugs, and that’s why some nootropics are commonly taken to treat neurodegenerative disorders like Alzheimer’s disease.

Nootropics can either be natural or synthetic. Natural nootropics are formulated using organic or plant-based ingredients. On the other hand, synthetic nootropics are made in laboratories. Both of them work almost the same way to deliver the desired results.

Omberacetam is a great example of a synthetic nootropic.

noopept

What is Noopept?

Noopept is one of the fastest-acting nootropics on the market. It was developed back in the 1990s by T.A Gudasheva from a Russian firm called Zakusov Institute of Pharmacology. The chemical structure of Noopept is based on another popular nootropic known as Piracetam. Sometimes the two are even confused, but they are not the same. Noopept is superior in that it is more potent (up to 1000 times more powerful than Piracetam!), and it has a shorter half-life. People use small doses of Noopept and still get to experience its full effects.

The drug has an extremely short half-life, so it leaves your system a lot faster than Piracetam does. However, one of the Noopepts metabolites called cycloprolyglycine (cPG) remains at high levels in the brain. Studies show that this metabolite is responsible for the many long-term cognitive benefits of Noopept.

We must point out that the research on Noopept is very limited. The suggested mechanism of action plus the effects of this drug are mostly based on animal studies. However, from the little research and anecdotal evidence available, it’s evident that the nootropic is a very promising drug with lots of potential. Many users report feeling increased energy levels and alertness in under an hour of taking the drug. It helps them acquire and process more information a lot faster than they usually do. Also, unlike Piracetam, the risk of experiencing psychostimulatory side effects is much lower when using Omberacetam.

Research also shows that Noopept can deliver neuroprotective benefits making it an interesting prospect for Alzheimer’s researchers.

How Does It Work?

The working mechanism of Noopept is not 100% understood because of how complex the brain works. However, multiple studies have provided a few details showing how this drug can enhance cognitive functions.

Some studies report that the nootropic improves neural responses to a neurotransmitter known as acetylcholine. Acetylcholine plays a vital role in various cognitive functions, such as learning. Therefore, by boosting neural responses to the neurotransmitter, Noopept improves your ability to learn, and it promotes other aspects of your cognition.

NGF and BDNF are vital neurotrophin proteins that enhance your memory and cognition. Omberacetam is also said to increase the expression of both NGF and BDNF neurotrophin proteins.

It modulates the activities of two glutamate receptors; AMPA and NMDA. The receptors regulate synaptic plasticity, which helps with learning and memory. By modulating the receptors, Noopept also prevents neuronal damage caused by glutamate toxicity.

Finally, Noopept has anti-inflammatory and antioxidant properties that provide neuroprotection. They prevent inflammation of the brain and oxidative stress; both are known to damage brain cells and affect cognition.

Benefits

  1. Improves Learning and Memory

Noopept improves memory and learning ability by enhancing neuroplasticity. It increases your ability to form new memories and retrieve old memories with ease.

The product also improves your ability to absorbs details and process information. This is a useful benefit not just to students and professionals but also for old/senior people who have a hard time remembering some basic details.

One significant benefit Omberacetam has over Piracetam is it improves the different phases of information processing, i.e., initial processing, consolidation, and retrieval.

Users also report improved sensory perception. Both hearing and vision improve significantly.

  1. Boosts Neuroprotection

Omberacetam is a powerful antioxidant that protects the brain against oxidative damage. Oxidative stress is a serious issue linked to cognitive decline and disorders like Alzheimer’s disease and other forms of dementia.

The drug also provides anti-inflammatory protection. Studies show that inflammations in the brain can cause loss of short-term memory, spatial reasoning, and verbal learning.

In addition to offering the above protection, It enhances the functioning of the brain by boosting blood flow to ensure that the cells are nourished at all times.

  1. Relieves Anxiety

Animal studies and a few human trials show that the supplement can reduce anxiety. However, the human trials were done on subjects with mild cognitive disorders, so it’s hard to tell whether the drug will be as effective in healthy people or individuals with advanced cognitive issues.

  1. Enhances Mood

Users report an elevated mood and an increase in motivation. It is still unclear how exactly it achieves this, but it may be a by-product of anxiety relief.

Side Effects

It pept is 1,000 times more powerful than Piracetam, so you must be very careful when dosing it. Taking it in high doses can result in adverse reactions like:

  • Anxiety
  • Headaches
  • Fatigue
  • Restlessness
  • Insomnia
  • Dizziness
  • Irritability

Consult a licensed physician before taking Omberacetam if you are pregnant, breastfeeding, or taking medications for different conditions.

Dosage

Given this drug’s insane potency, it’s wise to start with low doses of around 5mg taken two or three times a day. You can test the waters with this dosage for 2 days or so. Proceed to increase the dosage to 10mg taken twice/thrice a day if you do not experience any adverse reactions.

It should be taken in small doses several times a day. This is much safer than taking it once in large doses. The drug should also be used for 1.5 to 3 months max, followed by a 1-month break. Taking breaks in-between cycles prevents the buildup of tolerance.

The product should be taken after a meal, and avoid using it in the evening or at night at it can interfere with your sleep.

Where to buy Oberacetam

The only major challenge with the product is the lack of enough clinical trials. This makes it really hard for us to fully understand how exactly it affects the brain and the full short and long-term benefits of using it. That said, the little information available is very promising. Anecdotal evidence is also too compelling to ignore the drug, and that’s why Noopept is worth checking out.

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08Dec

ACP-105: Dosage, Usage and Benefits

ACP-105 is a SARM, or selective androgen receptor modulators, that was created to help individuals with degenerative bone disorders. Due to the nature of the supplement and its potential for increased muscle growth, it is also regularly used by individuals interested in muscle and bodybuilding. Overall, the drug helps individuals to build endurance, gain lean muscle, and increase strength.

Medical History

In 2008 the biopharmaceutical company ACADIA Pharmaceuticals announced its plans to reveal their novel nonsteroidal SARM, ACP-105, among other things. The company promoted that, in lab studies, their nonsteroidal SARM worked just as well as testosterone and showed strong anabolic effects on bones and muscles. They believed that this would advance the treatment of muscle-wasting conditions and osteoarthritis with less adverse effects than that of standard treatments.

This SARM works in a similar way that testosterone does, by binding onto each androgen receptor and work to reduce lipoproteins in the body while building mass that enables muscle growth, all without damaging any critical organs.

Benefits

Whether it is being used by bodybuilders or by those diagnosed with musculoskeletal disorders, ACP-105 comes with a host of benefits for those that use it. These benefits can include:

  • Quick and effective healing from injury or over-exhaustion.
  • The enhancement of cognitive skills and memory due to the increase of androgenic receptors in the brain.
  • Increases energy and stamina.
  • A significant increase in muscle mass is noticeable within the first week of use.
  • Reduces muscle waste and encourages its growth.
  • It allows the body to utilize abnormal fat and burn it off.
  • It could potentially be used for curing prostate and breast cancer as well as cachexia.
  • Reduces water retention and bloating due to it being non-aromatized.
  • It is stronger than testosterone pills and safer to use than regular steroids.

Side Effects

Much like with other supplements, using ACP-105 comes with the varied risk of side effects. None of these possible side effects have been documented as permanent. They all can be reversed by implementing post-cycle therapy, or PCT after a round of the nonsteroid supplement. Since it is not a potent SARM, a weaker, more natural PCT can be used instead.

Side effects of taking this drug can include a mild headache, which usually begins after the first use of the product and will disappear as the body becomes accustomed to the supplement. But if individuals begin taking higher than the recommended dose, the headache will return and stay with the individual as long as they are taking the increased dosage. Fatigue and nausea, especially after week seven to eight of use, can indicate the suppression of testosterone. This is when it is advisable to go for a round of post-cycle therapy in order to refresh the body.

Dosage

When deciding to use ACP-105, following the recommended dosage guidelines is essential for preventing increasingly strong side effects and getting the most out of this SARM.

If the drug is being used for a musculoskeletal disorder, then a doctor will be able to give a proper dosage for the ailment. If it is instead being used by individuals wanting to build more muscle during workouts, the dosage will change depending on whether they are male or female. A female is recommended to 5 mg of the drug a day for eight weeks. In contrast, a male is recommended to take 10 mg a day for eight to twelve weeks. If the individual wishes to continue taking the drug after their recommended time frame, then a round of post-cycle therapy can be done before starting the regimen over again.

ACP-105 promotes muscle gain as well as increased strength and stamina in individuals that take it. With it being a relatively less potent SARM, with less intense side effects, it is generally recommended as a good product for use in bulking muscle and cutting fat. As with most supplements and SARMs, it is not approved for use by the FDA and should be taken under guidance from a doctor.

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08Dec

Acetyl-L-Carnitine: Usage, Side Effects and Dosage

Acetyl-L-Carnitine or ALCAR is made in the body from L-carnitine, which is a by-product of an amino-acid. ALCAR can be obtained naturally from animal sources such as milk, cheese, chicken, or beef. It is broken down in the body into carnitine. This is then used by the body to help transport fatty acids into the mitochondria for conversion into energy.

Acetyl-L-Carnitine

Medical History

A variety of studies have been conducted over the last decade to gauge the effectiveness of ALCAR as a treatment for various ailments. These ailments include male infertility, depression, and diabetic peripheral neuropathy, to name a few. While overall, these specific study trials showed positive results, they could not be verified due to their inconsistencies or small study size.

Benefits

While official scientific research has not been done on all the benefits of ALCAR, there are positive results in many individuals who have taken it for various reasons. Individuals take this supplement for benefits, including:

  • Increases energy in the older population that is experiencing lethargy and fatigue.
  • A reduction of diabetic neuropathy or nerve pain in those with diabetes.
  • Reducing memory loss in older individuals.
  • A reduction of depression, fatigue, and sexual dysfunction in males experiencing low testosterone.
  • A reduction of the need for pain medications for sciatic nerve pain.
  • Reduces the pain and slows the progression of Peyronie disease, which causes painful, curved erections.
  • Increases the chance of survival and improves the physical function of individuals diagnosed with ALS if given along with the drug riluzole.
  • Slows the rate of progression of Alzheimer’s disease and shows a marked improvement in mental function and behavior in patients already suffering from the disease.
  • A reduction of depression symptoms in the older population.
  • Increases sperm count and movement in men with fertility problems.
  • Reduces the symptoms of fibromyalgia if given both by mouth and injection.

Side Effects

While ALCAR is generally considered safe for use by most people, there have been some reported side effects. These side effects include headaches, trouble sleeping, stomach pain, diarrhea, nausea, vomiting, and raised blood pressure. Some individuals with a specific diagnosis are recommended not to take this supplement due to the likelihood of increasingly detrimental side effects. Individuals with seizures run the risk of increasing the amount and seriousness of their seizures if they choose to take ALCAR. Those that have been diagnosed with bipolar disorder have an increased likelihood of psychosis if taking the supplement. Individuals with nerve damage in the hands or feet are not recommended to take the supplement due to a risk of their nerve damage worsening. This supplement is also not recommended for children or women that are pregnant or breastfeeding due to the lack of reliable information on how the drug will affect these individuals.

Acetyl-L-carnitine has been shown to interact negatively with the blood thinners Warfarin and Acenocoumarol and, therefore, should not be taken by individuals that are prescribed these medications. This supplement can increase the effectiveness of these blood thinners too much and cause an increased chance of bleeding or bruising.

Dosage

The recommended dosage of acetyl-L-carnitine is dependent on what it is being taken for. Those who choose to take the supplement to increase their energy will require a different dosage than someone taking it to slow the progression rate in Alzheimer’s disease.

Individuals wishing to combat Alzheimer’s disease progression or reduce their memory loss are recommended to take 1500-3000 mg of ALCAR daily for three months. Those wanting to increase their energy and reduce their fatigue are recommended 2 grams of the supplement be taken for six months. In order to reduce the symptoms of depression, the dosage of 1-4 grams of acetyl-L-carnitine is recommended. Those individuals with diabetic neuropathy pain are suggested to take 1500-3000 mg of the supplement for up to a year. Men who suffer from infertility or Peyronie disease are recommended to take 1 gram of ALCAR, one to two times a day, for three months.

Acetyl-L-Carnitine is a beneficial supplement to many individuals. Fatigue, memory loss, and symptoms of depression have been shown to be reduced with the regular consumption of this supplement. With more scientific research being done all the time, it’s only a matter of time until more benefits of it are discovered.

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08Dec

Dihydroxyflavone: Usage, Side Effects and Dosage

Dihydroxyflavone, particularly 7,8-dihydroxyflavone, is a plant compound currently being researched for its therapeutic ability in central nervous system disorders. While it is still in its clinical research phase, 7,8-dihydroxyflavone has shown promise as being a beneficial supplement for improving memory, executive functions, creativity, and motivation.

Dihydroxyflavone

Medical History

7,8-Dihydroxyflavone, or 7,8-DHF, was discovered by accident by scientists researching a compound comparable to the brain-derived neurotrophic factor, or BDNF. BDNF helps to promote the growth of neurons and synapses that are vital for healthy cognitive function. But BDNF was having difficulty influencing this growth in animal trials because of its lack of bioavailability and its inability to pass the blood-brain barrier.

It was found that 7,8-dihydroxyflavone not only had efficient oral bioavailability but that it could also pass the blood-brain barrier with ease. This allowed 7,8-DHF to turn on the tropomyosin-related kinase B receptors that would prompt an increase in neuron and synapsis growth. It also increased the body’s production of nuclear factor (erythroid-derived 2)-like 2, which antioxidant enzymes as well as enzymes that promote DNA repair.

Benefits

7,8-Dihydroxyflavone has currently only been studied in animal trials, and thus we can not be sure how the compound may affect humans. The research, as of current, denotes possible cognitive health benefits. These potential benefits include:

  • Brain repair for those that sustained a traumatic brain injury.
  • Improved memory and learning while decreasing the mental defects of schizophrenia.
  • Improvement in memory and learning in healthy subjects.
  • Improvement of neuron survival and motor defects attributed to amyotrophic lateral sclerosis, or ALS.
  • Noted memory improvements in aging subjects or those with Dementia.
  • Helped to decrease inflammation in brain cells.
  • Delayed cognitive and motor impairment in the model subjects for Huntington’s disease.
  • Reduced fat production and build-up.
  • Protection against stroke-related brain damage, with more benefits exhibited in female subjects.
  • Reduced oxidative stress and the formation of amyloid plaque while preventing memory defects and a loss of synapsis in subjects used to model Alzheimer’s disease.
  • Slowing the disease progression and severity of multiple sclerosis, or MS.
  • In subjects used to model Parkinson’s disease, it improved motor function.
  • Reduced depression and depressive behaviors.
  • Increased antioxidant enzyme levels and collagen production while decreasing inflammation in aged skin cells.

The research done to test these benefits used mice and rat subjects with similar cellular or cognitive defects that a human diagnosed with such diseases would have. When animal subjects weren’t beneficial, such as with the research into skin aging, human cells were used instead.

Side Effects

As the Dihydroxyflavone 7,8 has not proceeded yet with human trails, once again, the side effects can only be obtained from the animal research subject. Therefore it is still unknown what types of side effects would be observed in humans as well as any possible drug interactions.

The current observation of side effects in animal subjects includes restlessness, dizziness, overstimulation, irritability, nausea, and trouble sleeping.

Dosage

Dihydroxyflavone, particularly 7,8-dihydroxyflavone, has not been officially approved for human consumption due to the lack of human testing and uncertain benefits and side effects in humans. Because of this, there is no safe and effective recommended dosage, even though the compound is available in powdered and capsule forms.

In animal subjects, 5 mg/kg was given to mice that cognitive issues, 10 mg/kg were given to rats with no cognitive issues, and 30 mg/kg seemed to be the most effective dose in the mouse subject. While it is prudent to confer with a doctor before deciding to consume this compound, the standard dosage in the commercially available supplements recommends 10-30 mg be taken a day.

Overall, dihydroxyflavone, specifically 7,8-dihydroxyflavone, holds a lot of promise as a future beneficial cognitive improvement supplement. More research and human trials will be required to prove its efficiency at improving cognitive function in humans.

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