Last updated on July 21st, 2021 at 11:59 am

Cyclazodone is a stimulant drug that is used to help enhance the mental focus of an individual and has found recent attention as a study aid. It is a derivative of pemoline but exhibits more potent stimulating and nootropic properties than it. The patents for the drug detail that it reduced fatigue with less stimulatory activity and less toxicity than that of amphetamines. While the drug has the possibility of being a potent nootropic and stimulant, the FDA has not approved it to be used as such due to the lack of scientific information and clinical trials.


Medical History

Cyclazodone was formulated in the 1960s by the American Cyanamid Company but was not widely known before it appeared online in the research chemical market in 2017. The effects of the drug are similar to those produced by amphetamines, and there is concern about it becoming an addictive substance due to its being used recreationally. Caution should be taken when consuming the drug, as there is an overall lack of pharmacological information and limited clinical data available for the drug. Therefore there is no sure way of knowing how toxic the drug can be or how severe the reactions may be from long-term usage.


The benefits of Cyclazodone are unsubstantiated in the scientific community and can not be accurately surmised because of this. Any potential benefits noted are from scientific theories on how the drug may work or personal anecdotes from current users of the drug. The possible benefits of the drug include:

  • Provides cognitive and physical stimulation
  • Increases mental alertness and focus
  • Increases energy
  • Decreases drowsiness
  • Positive improvement on an individual’s mood
  • Increased sociability
  • Promotes a euphoric feeling
  • An increased relief from pain
  • A reduction of symptoms of anxiety
  • Increased confidence and self-esteem
  • Increased libido
  • Enhanced clarity of thought
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Side Effects

There have been no human studies to prove Cyclazodone’s safety, and it is recommended to use harm reduction practices if an individual chooses to consume the drug. A wide range of reactions have been noted by personal usage, but very little scientific evidence is available. It is generally understood that most adverse reactions happen when an individual takes a higher dosage, while lower dosing seems to be relatively safe. The potential side effects of the drug include frequent urination, increased body temperature, temporary erectile dysfunction, dry mouth, compulsive redosing, increased heart rate, teeth grinding, muscle cramps, a change in appetite, nausea, increased anxiety, headache, and irritability.

Unlike some drugs, there are also after-effects that are associated with taking this drug. These after-effects can include cognitive fatigue, headaches, a lack of motivation, muscle cramps, delusions, anxiety, depression, psychosis, depersonalization, insomnia, tactile hallucinations, and slowed down thoughts.

It is not advised to combine the drug with other substances, as it can cause moderate to severe reactions in some cases. It should not be taken with alcohol, MDMA, cocaine, Tramadol, and any other stimulant drug.


Cyclazodone is not approved by the FDA and does not have standard safe dosing guidelines. It is recommended to take the drug under the guidance of a healthcare provider for the safest experience. Individuals who wish to try the drug are also advised to take the lowest recommended dose in order to gauge their body’s reaction to the drug.

The dosage guidelines for research purposes denote a low dose as 5 mg and should be taken irregularly to prevent a tolerance build-up. A moderate dose is between 5 mg to 15 mg and should also be taken irregularly. Finally, a strong dose is listed at 25 mg to 30 mg, and no more than that should be taken at once. The drug is sold in pill and powder form from a 1 mg dosage to a 30 mg dose.

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Overall, Cyclazodone is a potential beneficial stimulant and nootropic. More scientific research is needed to determine its benefits and safety. While the drug can be taken for research purposes and to treat those with ADHA, caution is recommended due to the current lack of information on its side effects and toxicity.

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