{"id":1021,"date":"2020-12-23T15:48:08","date_gmt":"2020-12-23T15:48:08","guid":{"rendered":"http:\/\/rhtp.org\/?p=1021"},"modified":"2022-04-01T12:03:13","modified_gmt":"2022-04-01T12:03:13","slug":"sunifiram","status":"publish","type":"post","link":"https:\/\/rhtp.org\/sunifiram\/","title":{"rendered":"Sunifiram: Usage, Benefits &#038; Dosage"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_69_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-673fc181210ff\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-673fc181210ff\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/rhtp.org\/sunifiram\/#Mechanism-of-Action\" title=\"Mechanism of Action\">Mechanism of Action<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/rhtp.org\/sunifiram\/#Uses-and-Benefits\" title=\"Uses and Benefits\">Uses and Benefits<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/rhtp.org\/sunifiram\/#Side-Effects\" title=\"Side Effects\">Side Effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/rhtp.org\/sunifiram\/#Dosage\" title=\"Dosage\">Dosage<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/rhtp.org\/sunifiram\/#Can-You-Stack-Sunifiram-with-Other-Nootropics\" title=\"Can You Stack Sunifiram with Other Nootropics?\">Can You Stack Sunifiram with Other Nootropics?<\/a><\/li><\/ul><\/nav><\/div>\n\n<p>Sunifiram or DM-235 is a relatively new research chemical categorized as a nootropic or cognitive enhancing drug. It is derived from <a href=\"https:\/\/rhtp.org\/piracetam\/\">Piracetam<\/a>, another very popular nootropic. Unlike <a href=\"https:\/\/rhtp.org\/best-racetam-for-energy\/\">racetams<\/a>, Sunifiram is more potent, with data showing that it is 1000 times more powerful than Piracetam!<\/p>\n\n\n\n<p>According to the scientific evidence available at the moment, it can boost memory, learning ability, and mood. It may also boost energy levels.<\/p>\n\n\n\n<p>Sunifiram was developed in 2000 by scientists from the University of Firenze, Italy. It was initially developed for treating the cognitive decline symptoms of Alzheimer's disease. The research was sadly abandoned, so they didn't publish any clinical data.<\/p>\n\n\n\n<p>Today, Sunifiram is available as a research chemical. The FDA has not approved the use of the drug for any medicinal uses. They also do not regulate it, so people can buy from online stores as a dietary supplement.<\/p>\n\n\n\r\n        <div class=\"p-4 my-4 text-base bg-gray-100 border-gray-100 border-solid rounded-lg shadow-lg egg-product-card-container style-3\">\r\n        <div class=\"grid gap-5 sm:grid-cols-9\">\r\n            <div class=\"self-start sm:col-span-3\">\r\n                                <div class=\"p-4 text-sm text-center bg-white border border-gray-200 border-solid rounded-lg shadow-sm\">\r\n                    <a\r\n                        data-merchant=\"chemyo.com\"\r\n                        data-template=\"Product Card (Style 3)\"\r\n                        rel=\"nofollow\"\r\n                        target=\"_blank\"\r\n                        href=\"https:\/\/rhtp.org\/check\/112\"\r\n                    >\r\n                        <img fetchpriority=\"high\" decoding=\"async\"\r\n                            width=\"442\"\r\n                            height=\"700\"\r\n                            class=\"block object-contain h-auto max-w-full mx-auto mb-2 max-h-32\"\r\n                            src=\"https:\/\/www.chemyo.com\/wp-content\/uploads\/2020\/09\/SUNIFIRAM_POWDER_F.png\"\r\n                            alt=\"Sunifiram Powder - 10g\"\r\n                        \/>\r\n                        <div class=\"mt-2 w-4 inline-block relative top-[3px] mr-1 svg\">\r\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\"><!--! Font Awesome Pro 6.0.0 by @fontawesome - https:\/\/fontawesome.com License - https:\/\/fontawesome.com\/license (Commercial License) Copyright 2022 Fonticons, Inc. --><path d=\"M152 120c-26.51 0-48 21.49-48 48s21.49 48 48 48s48-21.49 48-48S178.5 120 152 120zM447.1 32h-384C28.65 32-.0091 60.65-.0091 96v320c0 35.35 28.65 64 63.1 64h384c35.35 0 64-28.65 64-64V96C511.1 60.65 483.3 32 447.1 32zM463.1 409.3l-136.8-185.9C323.8 218.8 318.1 216 312 216c-6.113 0-11.82 2.768-15.21 7.379l-106.6 144.1l-37.09-46.1c-3.441-4.279-8.934-6.809-14.77-6.809c-5.842 0-11.33 2.529-14.78 6.809l-75.52 93.81c0-.0293 0 .0293 0 0L47.99 96c0-8.822 7.178-16 16-16h384c8.822 0 16 7.178 16 16V409.3z\"\/><\/svg>                        <\/div> Show more photos                    <\/a>\r\n                <\/div>\r\n                            <\/div>\r\n            <div class=\"sm:col-span-6\">\r\n                <h4 class=\"mt-0 mb-2 text-lg font-semibold leading-5 sm:text-2xl line-clamp-2\">\r\n                    <a\r\n                        data-merchant=\"chemyo.com\"\r\n                        data-template=\"Product Card (Style 3)\"\r\n                        class=\"text-gray-700 hover:no-underline\"\r\n                        rel=\"nofollow\"\r\n                        target=\"_blank\"\r\n                        href=\"https:\/\/rhtp.org\/check\/112\"\r\n                    >\r\n                        Sunifiram Powder - 10g                    <\/a>\r\n                <\/h4>\r\n                \r\n                <div class=\"flex\">\r\n                    <img decoding=\"async\"\r\n                        class=\"relative top-0.5 mr-2  self-center\"\r\n                        width=\"16\"\r\n                        height=\"16\"\r\n                        src=\"https:\/\/rhtp.org\/wp-content\/uploads\/ce-logos\/icon_chemyo-com.png\"\r\n                    \/>\r\n                    <a\r\n                        data-merchant=\"chemyo.com\"\r\n                        data-template=\"Product Card (Style 3)\"\r\n                        class=\"inline-block px-5 py-2 my-3 text-xl text-center text-black bg-yellow-400 rounded-sm affegg-btn hover:shadow-md hover:no-underline sm:px-2 sm:px-10 sm:text-xl\"\r\n                        rel=\"nofollow\"\r\n                        target=\"_blank\"\r\n                        href=\"https:\/\/rhtp.org\/check\/112\"\r\n                    >\r\n                        Check best price                    <\/a>\r\n                <\/div>\r\n\r\n                <div class=\"mt-3 text-sm text-gray-500\">\r\n                    \n\n\n\n\n\nThird-party tested&nbsp;for identity &&nbsp;purity Sealed in an\nairtight waterproof bag Free shipping US $100+ | international\n$275+\n\n                <\/div>\r\n                            <\/div>\r\n      <\/div>\r\n    <\/div>\r\n  \n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mechanism-of-Action\"><\/span>Mechanism of Action<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The mechanism of action of Sunifiram is not 100% understood. Based on its striking similarities to Piracetam, some studies suggest that it affects the brain the same way Piracetam does. No reliable human trials support the claim, though.<\/p>\n\n\n\n<p>Based on the limited research, scientists have put across several possible mechanisms of action explaining how the nootropic can be beneficial.<\/p>\n\n\n\n<p>First, animal studies have reported that Sunifiram improves acetylcholine activities in the brain. In a study done on mice, the drug fought scopolamine, a compound that inhibits the release of acetylcholine. The neurotransmitter acetylcholine plays a vital role in learning, memory, and other brain functions. This would explain how this nootropic is believed to be an effective nootropic as well as a treatment for cognitive decline associated with Alzheimer\u2019s disease.<\/p>\n\n\n\n<p>It\u2019s also possible that Sunifiram improves learning and cognition by activating the <a href=\"https:\/\/www.pnas.org\/content\/112\/51\/15749\" class=\"rank-math-link\" target=\"_blank\" rel=\"noopener\">AMPA-mediated neurotransmission system<\/a>.<\/p>\n\n\n\n<p>According to another study done on mice, Sunifiram stimulated the release of glutamate and activated the glutamate receptors. This boosts synaptic plasticity, which is essential for learning and other cognitive functions.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/rhtp.org\/open\/chemyo-nootropics\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" width=\"850\" height=\"500\" src=\"https:\/\/rhtp.org\/wp-content\/uploads\/2022\/03\/Chemyo-nootropics.png\" alt=\"Chemyo - third party Fladrafinil \" class=\"wp-image-3783\" srcset=\"https:\/\/rhtp.org\/wp-content\/uploads\/2022\/03\/Chemyo-nootropics.png 850w, https:\/\/rhtp.org\/wp-content\/uploads\/2022\/03\/Chemyo-nootropics-300x176.png 300w, https:\/\/rhtp.org\/wp-content\/uploads\/2022\/03\/Chemyo-nootropics-768x452.png 768w\" sizes=\"(max-width: 850px) 100vw, 850px\" \/><\/a><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Uses-and-Benefits\"><\/span>Uses and Benefits<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Most of the uses and benefits of Sunifiram are mostly theoretical. The drug is relatively new in the scene, and it hasn't been subjected to any reliable human trials. The uses discussed below are based on the preliminary data from limited animal studies.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Improves Memory and Learning<\/strong><\/li><\/ul>\n\n\n\n<p>Multiple animal studies have reported Sunifiram\u2019s ability to improve memory and learning. In some of these studies, the researchers looked at the impact of Sunifiram on mice with amnesia induced by drugs like baclofen, clonidine, and scopolamine. The researchers observed significant improvements suggesting Sunifiram may be effective in reversing memory loss issues caused by certain medications. While the results are very promising, they are far from definitive because they are limited to animal subjects. Also, the study involved subjects that had been treated with memory-impairing drugs. It\u2019s impossible to tell whether they can boost memory in healthy individuals.<\/p>\n\n\n\n<p>Since this nootropic can influence acetylcholine activities, it\u2019s also possible that it can improve learning. A few studies have suggested this usage, but they were all done on mice.<\/p>\n\n\n\n<p>Large-scale clinical trials are necessary to understand the efficacy and safety of Sunifiram fully.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>May Reduce Pain Sensitivity<\/strong><\/li><\/ul>\n\n\n\n<p>In a trial involving rats subjected to heat-related pain, the researchers reported that the mice treated with Sunifiram had a better response to the pain.<\/p>\n\n\n\n<p>Other than the above benefits, a few trials also claim the nootropic can increase sex drive, improve mood, and boost energy levels.<\/p>\n\n\n\n<p>The biggest drawback with Sunifiram is the lack of extensive clinical studies, meaning we cannot say tell with absolute certainty whether the drug is as beneficial as claimed or not.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side-Effects\"><\/span>Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright size-full is-resized\"><a href=\"https:\/\/rhtp.org\/visit\/noocube\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/rhtp.org\/wp-content\/uploads\/2022\/03\/noocube-side-banner.png\" alt=\"Noocube Fladrafinil\" class=\"wp-image-3775\" width=\"324\" height=\"617\" srcset=\"https:\/\/rhtp.org\/wp-content\/uploads\/2022\/03\/noocube-side-banner.png 420w, https:\/\/rhtp.org\/wp-content\/uploads\/2022\/03\/noocube-side-banner-158x300.png 158w\" sizes=\"(max-width: 324px) 100vw, 324px\" \/><\/a><\/figure><\/div>\n\n\n\n<p>Again, due to the lack of sufficient clinical trials, the safety of Sunifiram remains mostly unknown. Another concern is its potency, which is reported to be 1000 times higher than <a href=\"https:\/\/rhtp.org\/piracetam\/\" class=\"rank-math-link\">Piracetam\u2019s<\/a>. Being such a powerful compound, Sunifiram may induce some serious adverse events if used recklessly.<\/p>\n\n\n\n<p>So far, the only adverse reactions reported are headaches, increased perspiration, high body temperature, nasal stuffiness, insomnia, restlessness, forgetfulness, mental sluggishness or brain fog, <a href=\"https:\/\/rhtp.org\/best-kratom-for-anxiety\/\">anxiety<\/a>, and increased sensitivity to audio and visual stimulation.<\/p>\n\n\n\n<p>The smart thing to do is avoid using Sunifiram until we have enough scientific evidence documenting its benefits and safety. However, if you still want to use it, you should do so under the guidance of a licensed physician. Make sure to follow the recommended dosage at all times. You should also avoid using it for a prolonged period.<\/p>\n\n\n\n<p>Consult a physician before taking the supplement if you have an existing medical condition. Pregnant and nursing mothers should avoid the drug.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dosage\"><\/span>Dosage<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>There are no official dosages of this drug. The dosage guideline available at the moment is based on anecdotal experiences. Given the extreme potency of the drug, users require only small doses to feel its effects.<\/p>\n\n\n\n<p>Most people experimenting with the drug use it in dosages of between 5 and 10mg taken two or three times per day.<\/p>\n\n\n\n<p>Using it in high doses or for too long can lead to tolerance so, it should be used in short cycles with breaks in between.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Can-You-Stack-Sunifiram-with-Other-Nootropics\"><\/span>Can You Stack Sunifiram with Other Nootropics?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The practice of stacking multiple <a href=\"https:\/\/rhtp.org\/noopept-the-complete-guide\/\">nootropics<\/a> to boost the results has grown very popular in the last few years. Most of these stacks work quite well without causing any adverse reactions. This is especially common in people who already have vast experience with these drugs.<\/p>\n\n\n\n<p>Theoretically, the product can also be stacked with other nootropics, but that'll be ill-advised. There is so much about this drug that we do not know. This includes drug interactions and possible long-term side effects. It\u2019s also a very powerful compound. For such reasons, it\u2019s wiser to avoid combining Sunifiram with any other dietary supplements until more clinical trials on its effects and safety are published.<\/p>\n\n\n\n<p><em>References<\/em><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>https:\/\/examine.com\/supplements\/sunifiram\/<\/li><li>https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S096808960900830X<\/li><li>https:\/\/www.unboundmedicine.com\/medline\/citation\/16834757\/Pharmacological_characterization_of_DM232__unifiram__and_DM235__sunifiram__new_potent_cognition_enhancers_<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Sunifiram or DM-235 is a relatively new research chemical categorized as a nootropic or cognitive enhancing drug. It is derived<\/p>\n","protected":false},"author":1,"featured_media":1758,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rank_math_lock_modified_date":false,"footnotes":""},"categories":[28],"tags":[43,36],"class_list":["post-1021","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nootropics","tag-alzheimer","tag-smart-drugs"],"_links":{"self":[{"href":"https:\/\/rhtp.org\/wp-json\/wp\/v2\/posts\/1021","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rhtp.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rhtp.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rhtp.org\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rhtp.org\/wp-json\/wp\/v2\/comments?post=1021"}],"version-history":[{"count":4,"href":"https:\/\/rhtp.org\/wp-json\/wp\/v2\/posts\/1021\/revisions"}],"predecessor-version":[{"id":3935,"href":"https:\/\/rhtp.org\/wp-json\/wp\/v2\/posts\/1021\/revisions\/3935"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rhtp.org\/wp-json\/wp\/v2\/media\/1758"}],"wp:attachment":[{"href":"https:\/\/rhtp.org\/wp-json\/wp\/v2\/media?parent=1021"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rhtp.org\/wp-json\/wp\/v2\/categories?post=1021"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rhtp.org\/wp-json\/wp\/v2\/tags?post=1021"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}