Hydrafinil, otherwise known as 9-Fluorenol, is a eugeroic drug that promotes wakefulness and increased mental alertness in an individual. It is a metabolite of Modafinil but has a shorter half-life of six to eight hours. It operates by boosting the dopamine and norepinephrine in the brain, which increases glutamate, a neurotransmitter that enhances memory and learning. The increase of dopamine also triggers an increase in cognitive abilities and alertness. In comparison to other eugeroics, this drug has a more subtle impact on energy and function, allowing for a calmer, less wired energy.
Hydrafinil was created by Cephalon Pharmaceuticals as a possible successor to the popular eugeroic drug Provigil, also known as Modafinil. Research, at the time, pointed to the drug having 39% more viability over a short span of time than Modafinil. The company eventually scrapped research into the potential of the drug, possibly due to Fluorenol being used as a bug spray in the 1930s and being found to be lethal to aquatic life.
The drug is hailed at producing more potent euphoric and eugeroic effects than Modafinil, but for a shorter time. The shorter half-life of the drug is a draw-back to many individuals, as the benefits don’t last long before they expire.
Interest in the drug spiked again in 2015 when nootropic drugs became popular. It is not FDA regulated and can be purchased over the counter either online or in select nutrition stores as a dietary supplement.
Although Hydrafinil may be an unregulated drug, the benefits are widely noted due to it being comparable to Modafinil. Many individuals that have used the supplement report an increase in cognitive functions and clarity of thought. Other potential benefits of the supplement include:
- Increased energy and alertness
- Improved quality of sleep
- An increased attention span
- Increased capacity to learn
- Improved memory
- Increased motivation
- Improvement in mood
- A more regulated sleep cycle
- Less addictive than Modafinil
- Assist with overcoming addictions
The FDA does not regulate Hydrafinil, so caution must be taken when purchasing the supplement as different manufacturers can produce the supplement differently. In order to decrease the risk of contamination and severe side effects, a high-quality supplement from a reputable company is recommended.
Individuals that have used the drug have not reported any severe side effects, and it is generally considered to have fewer adverse reactions than that of Modafinil. The few mild side effects that have been reported include headaches, nausea, a change in appetite, dizziness, nervousness, increased anxiety, and difficulty sleeping.
As the drug has not gone through any human clinical trials, there is no accurate way of knowing the safety of its long term use. Because of this, it is not recommended for use by those that are pregnant or breastfeeding.
As it is an unregulated drug, Hydrafinil does not have any information regarding a standard dosage. Care should be taken to not consume too much of the supplement due to its increased strength in comparison to other eugeroic drugs. A doctor’s guidance is recommended when taking such a supplement to provide more accurate dosage recommendations.
Typically, manufacturers of the supplement prescribe standard dosing of 50 mg to 150 mg daily, with no more than 150 mg a day recommended. Taking the highest dosage for multiple days in a row is also not suggested.
Overall, Hydrafinil comes across as a strong eugeroic beneficial in supporting and improving the cognitive functions of the brain while also providing a stimulating boost of energy when it is needed most. At the present time, it is considered to be relatively safe to consume due to it being compatible with other scientifically backed drugs.