08Dec

Dihydroxyflavone: Usage, Side Effects and Dosage

Dihydroxyflavone, particularly 7,8-dihydroxyflavone, is a plant compound currently being researched for its therapeutic ability in central nervous system disorders. While it is still in its clinical research phase, 7,8-dihydroxyflavone has shown promise as being a beneficial supplement for improving memory, executive functions, creativity, and motivation. Medical History 7,8-Dihydroxyflavone, or 7,8-DHF, was discovered by accident by scientists researching a compound comparable to the brain-derived neurotrophic factor, or BDNF. BDNF helps to promote the growth of neurons and synapses that are vital for healthy cognitive function. But BDNF was having difficulty influencing this growth in animal trials because of its lack of bioavailability and its inability to pass the blood-brain barrier. It was found that 7,8-dihydroxyflavone not only had efficient oral bioavailability but that it could also pass the blood-brain barrier with ease. This allowed 7,8-DHF to turn on the tropomyosin-related kinase B receptors that would prompt an increase in neuron and synapsis…
08Dec

DMAA: Usage, Side Effects and Dosage

Methylhexanamine, or DMAA, is a synthetic drug created in a lab, originally used as a nasal decongestant via a nasal spray. It is an amphetamine derivative that is illegal in several countries. It is currently sold as a dietary supplement for increased energy, weight loss, and athletic performance. Due to safety concerns, the FDA is actively working on removing the commercial availability of dietary supplements containing DMAA. Medical History Created by Eli Lilly and Company in 1948 as a nasal decongestant, DMAA was used for many years until the company voluntarily recalled it in the 1970s. In 2006, it began to be used as a stimulate in various dietary supplements. Many dietary supplement manufacturers claimed that it was a naturally derived compound from the geranium plant and perfectly safe to use. Over time the drug’s safety was put into question due to the adverse effects it was giving users and…
08Dec

Adrafinil: Usage, Side Effects and Dosage

Adrafinil is an inactive eugeroic drug used in promoting increased cognitive abilities and alertness. As it is metabolized in the body, it is converted to the active drug Modafinil. It is typically utilized by individuals with sleep disorders that affect their ability to stay awake during the day, such as narcolepsy. Unlike other wakefulness aids, such as coffee, this particular stimulant drug does not incur jitteriness or an energy crash in the individuals that use it. Medical History Adrafinil was discovered in France in 1974 by the Louis Lafon Laboratories pharmaceutical company. Given the brand name Olmifon, it was put into circulation in France in 1985 to remedy narcolepsy and other similar sleep disorders. It remained in use as a prescription drug until 2011, when the manufacturing of it was discontinued. This was done, in part, due to the discovery and apparent cost-effectiveness of manufacturing Modafinil. The difference in the…
08Dec

Alpha GPC: Usage, Side Effects and Dosage

Alpha GPC, or Alpha-glycerophosphocholine, is a cholinergic compound found naturally in the brain. Supplements containing this compound has been shown to promote increased cognitive function, support cellular membranes, and boost athlete’s power output. This is done by the supplement, increasing a chemical in the brain called acetylcholine. Acetylcholine is essential for learning functions of the brain and memory. The supplement also holds promise in being a beneficial ergogenic, or wakefulness supplement, but more research is needed in this area. Medical History In the early 1990s, Alpha GPC was used in an Italian clinical trial to test its effectiveness in treating the cognitive decline experienced in individuals who had recently suffered a stroke. They treated 2,044 patients who had recently suffered a stroke with the supplement at 1,000 mg a day for 28 days and then 400 mg three times a day for the following five months. The ensuing evidence pointed to the…
08Dec

Hydrafinil: Usage, Side Effects and Dosage

Hydrafinil, otherwise known as 9-Fluorenol, is a eugeroic drug that promotes wakefulness and increased mental alertness in an individual. It is a metabolite of Modafinil but has a shorter half-life of six to eight hours. It operates by boosting the dopamine and norepinephrine in the brain, which increases glutamate, a neurotransmitter that enhances memory and learning. The increase of dopamine also triggers an increase in cognitive abilities and alertness. In comparison to other eugeroics, this drug has a more subtle impact on energy and function, allowing for a calmer, less wired energy. Medical History Hydrafinil was created by Cephalon Pharmaceuticals as a possible successor to the popular eugeroic drug Provigil, also known as Modafinil. Research, at the time, pointed to the drug having 39% more viability over a short span of time than Modafinil. The company eventually scrapped research into the potential of the drug, possibly due to Fluorenol being…

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